Exceptional Heterogeneity in Viral Evolutionary Dynamics Characterises Chronic Hepatitis C Virus Infection.

The treatment of HCV infection has seen significant progress, particularly since the approval of new direct-acting antiviral drugs. However these clinical achievements have been made despite an incomplete understanding of HCV replication and within-host evolution, especially compared with HIV-1. Her...

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Bibliographic Details
Main Authors: Jayna Raghwani, Rebecca Rose, Isabelle Sheridan, Philippe Lemey, Marc A Suchard, Teresa Santantonio, Patrizia Farci, Paul Klenerman, Oliver G Pybus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5025083?pdf=render