A Phase 2 Randomized Trial of a Rifapentine plus Moxifloxacin-Based Regimen for Treatment of Pulmonary Tuberculosis.

A Phase 2 Randomized Trial of a Rifapentine plus Moxifloxacin-Based Regimen for Treatment of Pulmonary Tuberculosis.

BACKGROUND:The combination of rifapentine and moxifloxacin administered daily with other anti-tuberculosis drugs is highly active in mouse models of tuberculosis chemotherapy. The objective of this phase 2 clinical trial was to determine the bactericidal activity, safety, and tolerability of a regim...

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Bibliographic Details
Main Authors: Marcus B Conde, Fernanda C Q Mello, Rafael Silva Duarte, Solange C Cavalcante, Valeria Rolla, Margareth Dalcolmo, Carla Loredo, Betina Durovni, Derek T Armstrong, Anne Efron, Grace L Barnes, Mark A Marzinke, Radojka M Savic, Kelly E Dooley, Silvia Cohn, Lawrence H Moulton, Richard E Chaisson, Susan E Dorman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4861335?pdf=render

Internet

http://europepmc.org/articles/PMC4861335?pdf=render

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