A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

Abstract Background Amyotrophic Lateral Sclerosis (ALS) is a fatal and progressive neurodegenerative disorder with identified genetic causes representing a significant minority of all cases. A GGGGCC hexanucleotide repeat expansion (HRE) mutation within the C9ORF72 gene has recently been identified...

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Bibliographic Details
Main Authors: Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown, Michael Benatar, Claes Wahlestedt, Christian Mueller, Zane Zeier
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis
C9ORF72 BAC mouse
Induced pluripotent stem cells
DNA methylation
Hydroxymethylation
R-loops
Online Access:http://link.springer.com/article/10.1186/s13024-017-0185-9

Internet

http://link.springer.com/article/10.1186/s13024-017-0185-9

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