T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response

T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response

Abstract Background Treatments for autoimmune diseases aim to dampen autoreactivity while preserving normal immune function. In CD4+ T cells, the transcription factor Oct1/Pou2f1 is a dispensable transcription factor for T cell development and response to primary infection, but promotes expression o...

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Bibliographic Details
Main Authors: Heejoo Kim, Laura Dickey, Colleen Stone, Jillian L. Jafek, Thomas E. Lane, Dean Tantin
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Neuroinflammation
Subjects:
Oct1/POU2F1
T lymphocytes
Experimental autoimmune encephalomyelitis
JHMV
Online Access:http://link.springer.com/article/10.1186/s12974-019-1523-3

Internet

http://link.springer.com/article/10.1186/s12974-019-1523-3

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