Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin.

Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin.

Many cancer research efforts focus on exploiting genetic-level features that may be targeted for therapy. Tissue-level features of the tumour microenvironment also represent useful therapeutic targets. Here we investigate the presence of low oxygen tension and sensitivity to NOS inhibition of tumour...

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Bibliographic Details
Main Authors: Jennifer H E Baker, Alastair H Kyle, Kirsten L Bartels, Stephen P Methot, Erin J Flanagan, Andrew Balbirnie, Jordan D Cran, Andrew I Minchinton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3810379?pdf=render

Internet

http://europepmc.org/articles/PMC3810379?pdf=render

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