Global, Regional, and National Burden of Endometrial Cancer, 1990–2017: Results From the Global Burden of Disease Study, 2017

Endometrial cancer (EC) is the most common malignancy affecting women in developed countries. Recently, the EC disease burden has changed; therefore, the Global Burden of Disease (GBD) 2017 was used to comprehensively analyze the global, regional, and national burden of EC between 1990 and 2017. Gen...

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Main Authors: Shuang Zhang, Ting-Ting Gong, Fang-Hua Liu, Yu-Ting Jiang, Hui Sun, Xiao-Xin Ma, Yu-Hong Zhao, Qi-Jun Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01440/full
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spelling doaj-9ae62fddf62848b19ca3524829fc3b6b2020-11-24T22:10:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-12-01910.3389/fonc.2019.01440497602Global, Regional, and National Burden of Endometrial Cancer, 1990–2017: Results From the Global Burden of Disease Study, 2017Shuang Zhang0Shuang Zhang1Ting-Ting Gong2Fang-Hua Liu3Fang-Hua Liu4Yu-Ting Jiang5Yu-Ting Jiang6Hui Sun7Hui Sun8Xiao-Xin Ma9Yu-Hong Zhao10Yu-Hong Zhao11Qi-Jun Wu12Qi-Jun Wu13Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, ChinaClinical Research Center, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, ChinaClinical Research Center, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, ChinaClinical Research Center, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, ChinaClinical Research Center, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, ChinaClinical Research Center, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, ChinaClinical Research Center, Shengjing Hospital of China Medical University, Shenyang, ChinaEndometrial cancer (EC) is the most common malignancy affecting women in developed countries. Recently, the EC disease burden has changed; therefore, the Global Burden of Disease (GBD) 2017 was used to comprehensively analyze the global, regional, and national burden of EC between 1990 and 2017. General GBD cancer estimation methods were used with the data input from vital registration systems and cancer registries. Annual percent changes were calculated to quantify the trends of EC burden estimates during the study period. Furthermore, the sociodemographic index (SDI) was used to assess the relationship between the EC burden estimates and development level. From 1990 to 2017, the age-standardized incidence and prevalence rate of EC increased globally by 0.58 and 0.89% per year, respectively. In contrast, the age-standardized death rate and disability-adjusted-life years (DALYs) decreased by 1.19 and 1.21% per year, respectively. Increasing trends in both the incidence and prevalence were observed in all SDI quintiles, except for the low SDI quintiles, whereas decreasing trends were observed in all SDI quintiles for mortality and DALYs. Additionally, a non-linear association existed for the level of mortality rate, DALYs, and SDI. Of note, there was a strong positive association between a high body mass index and DALYs across all SDI quintiles. In conclusion, EC incidence and prevalence rates are growing globally, whereas the death rate and DALYs decreased between 1990 and 2017. Greater efforts, particularly detailed prevention strategies for reducing obesity, should be performed to reverse this phenomenon.https://www.frontiersin.org/article/10.3389/fonc.2019.01440/fulldisability-adjusted life yearsdisease burdenendometrial cancerincidencemortalityprevalence
collection DOAJ
language English
format Article
sources DOAJ
author Shuang Zhang
Shuang Zhang
Ting-Ting Gong
Fang-Hua Liu
Fang-Hua Liu
Yu-Ting Jiang
Yu-Ting Jiang
Hui Sun
Hui Sun
Xiao-Xin Ma
Yu-Hong Zhao
Yu-Hong Zhao
Qi-Jun Wu
Qi-Jun Wu
spellingShingle Shuang Zhang
Shuang Zhang
Ting-Ting Gong
Fang-Hua Liu
Fang-Hua Liu
Yu-Ting Jiang
Yu-Ting Jiang
Hui Sun
Hui Sun
Xiao-Xin Ma
Yu-Hong Zhao
Yu-Hong Zhao
Qi-Jun Wu
Qi-Jun Wu
Global, Regional, and National Burden of Endometrial Cancer, 1990–2017: Results From the Global Burden of Disease Study, 2017
Frontiers in Oncology
disability-adjusted life years
disease burden
endometrial cancer
incidence
mortality
prevalence
author_facet Shuang Zhang
Shuang Zhang
Ting-Ting Gong
Fang-Hua Liu
Fang-Hua Liu
Yu-Ting Jiang
Yu-Ting Jiang
Hui Sun
Hui Sun
Xiao-Xin Ma
Yu-Hong Zhao
Yu-Hong Zhao
Qi-Jun Wu
Qi-Jun Wu
author_sort Shuang Zhang
title Global, Regional, and National Burden of Endometrial Cancer, 1990–2017: Results From the Global Burden of Disease Study, 2017
title_short Global, Regional, and National Burden of Endometrial Cancer, 1990–2017: Results From the Global Burden of Disease Study, 2017
title_full Global, Regional, and National Burden of Endometrial Cancer, 1990–2017: Results From the Global Burden of Disease Study, 2017
title_fullStr Global, Regional, and National Burden of Endometrial Cancer, 1990–2017: Results From the Global Burden of Disease Study, 2017
title_full_unstemmed Global, Regional, and National Burden of Endometrial Cancer, 1990–2017: Results From the Global Burden of Disease Study, 2017
title_sort global, regional, and national burden of endometrial cancer, 1990–2017: results from the global burden of disease study, 2017
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2019-12-01
description Endometrial cancer (EC) is the most common malignancy affecting women in developed countries. Recently, the EC disease burden has changed; therefore, the Global Burden of Disease (GBD) 2017 was used to comprehensively analyze the global, regional, and national burden of EC between 1990 and 2017. General GBD cancer estimation methods were used with the data input from vital registration systems and cancer registries. Annual percent changes were calculated to quantify the trends of EC burden estimates during the study period. Furthermore, the sociodemographic index (SDI) was used to assess the relationship between the EC burden estimates and development level. From 1990 to 2017, the age-standardized incidence and prevalence rate of EC increased globally by 0.58 and 0.89% per year, respectively. In contrast, the age-standardized death rate and disability-adjusted-life years (DALYs) decreased by 1.19 and 1.21% per year, respectively. Increasing trends in both the incidence and prevalence were observed in all SDI quintiles, except for the low SDI quintiles, whereas decreasing trends were observed in all SDI quintiles for mortality and DALYs. Additionally, a non-linear association existed for the level of mortality rate, DALYs, and SDI. Of note, there was a strong positive association between a high body mass index and DALYs across all SDI quintiles. In conclusion, EC incidence and prevalence rates are growing globally, whereas the death rate and DALYs decreased between 1990 and 2017. Greater efforts, particularly detailed prevention strategies for reducing obesity, should be performed to reverse this phenomenon.
topic disability-adjusted life years
disease burden
endometrial cancer
incidence
mortality
prevalence
url https://www.frontiersin.org/article/10.3389/fonc.2019.01440/full
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