Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue

Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue

Background: Many forms of hypertrophic cardiomyopathy (HCM) show an increased myofilament Ca2+ sensitivity. This observation has been mainly made in HCM mouse models, myofilament systems, and cardiomyocytes. Studies of multicellular tissues from patients with different HCM-associated gene mutations...

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Bibliographic Details
Main Authors: Nico Kresin, Sabrina Stücker, Elisabeth Krämer, Frederik Flenner, Giulia Mearini, Julia Münch, Monica Patten, Charles Redwood, Lucie Carrier, Felix W. Friedrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
myofilament
Ca2+ sensitivity
hypertrophic cardiomyopathy
MYBPC3
epigallocatechin-3-gallate
NanoString nCounter
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00239/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.00239/full

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