Design, synthesis and antimicrobial activity of new biquinoline derivatives

A simple and efficient method has been developed for the synthesis of some novel biquinoline derivatives bearing a thiazole moiety through a onepot three-component condensation of 2-chlro-3-formylquinolines, ethyl cyanoacetate and β-enaminone using catalytic amount of piperidine in refluxing eth...

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Main Authors:	Shah Nirav K., Shah Nimesh M., Patel Manish P., Patel Ranjan G.
Format:	Article
Language:	English
Published:	Serbian Chemical Society 2012-01-01
Series:	Journal of the Serbian Chemical Society
Subjects:	quinoline thiazole antibacterial antifungal
Online Access:	http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391100197S.pdf

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spelling	doaj-9b0143ec4ab244e08f15e4b2f8a5ed142020-11-24T21:26:10ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51392012-01-0177327928610.2298/JSC110630197SDesign, synthesis and antimicrobial activity of new biquinoline derivativesShah Nirav K.Shah Nimesh M.Patel Manish P.Patel Ranjan G.A simple and efficient method has been developed for the synthesis of some novel biquinoline derivatives bearing a thiazole moiety through a onepot three-component condensation of 2-chlro-3-formylquinolines, ethyl cyanoacetate and β-enaminone using catalytic amount of piperidine in refluxing ethanol. These molecules were evaluated in vitro for their antibacterial and antifungal activity. Most of the compounds exhibited moderate antibacterial and antifungal activity against all the tested strains.http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391100197S.pdfquinolinethiazoleantibacterialantifungal
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shah Nirav K. Shah Nimesh M. Patel Manish P. Patel Ranjan G.
spellingShingle	Shah Nirav K. Shah Nimesh M. Patel Manish P. Patel Ranjan G. Design, synthesis and antimicrobial activity of new biquinoline derivatives Journal of the Serbian Chemical Society quinoline thiazole antibacterial antifungal
author_facet	Shah Nirav K. Shah Nimesh M. Patel Manish P. Patel Ranjan G.
author_sort	Shah Nirav K.
title	Design, synthesis and antimicrobial activity of new biquinoline derivatives
title_short	Design, synthesis and antimicrobial activity of new biquinoline derivatives
title_full	Design, synthesis and antimicrobial activity of new biquinoline derivatives
title_fullStr	Design, synthesis and antimicrobial activity of new biquinoline derivatives
title_full_unstemmed	Design, synthesis and antimicrobial activity of new biquinoline derivatives
title_sort	design, synthesis and antimicrobial activity of new biquinoline derivatives
publisher	Serbian Chemical Society
series	Journal of the Serbian Chemical Society
issn	0352-5139
publishDate	2012-01-01
description	A simple and efficient method has been developed for the synthesis of some novel biquinoline derivatives bearing a thiazole moiety through a onepot three-component condensation of 2-chlro-3-formylquinolines, ethyl cyanoacetate and β-enaminone using catalytic amount of piperidine in refluxing ethanol. These molecules were evaluated in vitro for their antibacterial and antifungal activity. Most of the compounds exhibited moderate antibacterial and antifungal activity against all the tested strains.
topic	quinoline thiazole antibacterial antifungal
url	http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391100197S.pdf
work_keys_str_mv	AT shahniravk designsynthesisandantimicrobialactivityofnewbiquinolinederivatives AT shahnimeshm designsynthesisandantimicrobialactivityofnewbiquinolinederivatives AT patelmanishp designsynthesisandantimicrobialactivityofnewbiquinolinederivatives AT patelranjang designsynthesisandantimicrobialactivityofnewbiquinolinederivatives
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Design, synthesis and antimicrobial activity of new biquinoline derivatives

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