Epidemiology, Nasopharyngeal Carriage, Serotype Prevalence, and Antibiotic Resistance of Streptococcus pneumoniae in Indonesia

Abstract In Indonesia, pneumococcal disease represents a considerable public health concern; however, published data on the epidemiology, nasopharyngeal carriage, serotype prevalence, and antibiotic resistance of Streptococcus pneumoniae in this region are limited. Therefore, this article reviews th...

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Main Authors: Cissy B. Kartasasmita, Sri Rezeki Hadinegoro, Nia Kurniati, Rina Triasih, Carolina Halim, Amgad Gamil
Format: Article
Language:English
Published: Adis, Springer Healthcare 2020-08-01
Series:Infectious Diseases and Therapy
Subjects:
Online Access:https://doi.org/10.1007/s40121-020-00330-5
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spelling doaj-9b286ea0aeb1446d87c2875a0831df122021-09-05T11:14:36ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822020-08-019472373610.1007/s40121-020-00330-5Epidemiology, Nasopharyngeal Carriage, Serotype Prevalence, and Antibiotic Resistance of Streptococcus pneumoniae in IndonesiaCissy B. Kartasasmita0Sri Rezeki Hadinegoro1Nia Kurniati2Rina Triasih3Carolina Halim4Amgad Gamil5Department of Child Health, Universitas Padjadjaran/Hasan Sadikin General HospitalDepartment of Child Health, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo HospitalDepartment of Child Health, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo HospitalDepartment of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito HospitalPfizer IndonesiaPfizer Inc, Emerging Markets, Medical and Scientific AffairsAbstract In Indonesia, pneumococcal disease represents a considerable public health concern; however, published data on the epidemiology, nasopharyngeal carriage, serotype prevalence, and antibiotic resistance of Streptococcus pneumoniae in this region are limited. Therefore, this article reviews the available data from a variety of sources and also summarizes pneumococcal conjugate vaccine implementation and recommendations in Indonesia and subsequent impact on pneumococcal disease. Regional pneumococcal vaccination recommendations in Asia were also reviewed. Studies showed that pneumococcal nasopharyngeal carriage prevalence in Indonesia was approximately 43% to 55% in healthy children aged less than 5 years, which varied by age group, region, and year. Serotype analysis of pneumococcal nasopharyngeal carriage isolates in Indonesia revealed that 38% to 60% of isolates would be covered by the 13-valent pneumococcal conjugate vaccine (PCV13). The antimicrobial resistance of pneumococcal disease has increased over time; between 1997 and 2012, resistance to penicillin and sulfamethoxazole increased from 0% to 28% and 9% to 62%, respectively. Inclusion of pneumococcal conjugate vaccines into immunization programs is being implemented gradually. In 2017, Indonesia implemented a regional PCV13 immunization program in Lombok with a 2 + 1 vaccination schedule that was expanded in 2018–2019 to West Nusa Tenggara and Bangka Belitung Provinces; this expansion is predicted to substantially reduce the burden of pneumococcal disease in Indonesia. Overall, the limited data available regarding pneumococcal disease in Indonesia highlight the unmet need for comprehensive disease surveillance studies in this region that can help direct vaccination strategies.https://doi.org/10.1007/s40121-020-00330-5Antibiotic resistanceIndonesiaNasopharyngeal carriagePneumococcal diseasePneumococcal vaccination
collection DOAJ
language English
format Article
sources DOAJ
author Cissy B. Kartasasmita
Sri Rezeki Hadinegoro
Nia Kurniati
Rina Triasih
Carolina Halim
Amgad Gamil
spellingShingle Cissy B. Kartasasmita
Sri Rezeki Hadinegoro
Nia Kurniati
Rina Triasih
Carolina Halim
Amgad Gamil
Epidemiology, Nasopharyngeal Carriage, Serotype Prevalence, and Antibiotic Resistance of Streptococcus pneumoniae in Indonesia
Infectious Diseases and Therapy
Antibiotic resistance
Indonesia
Nasopharyngeal carriage
Pneumococcal disease
Pneumococcal vaccination
author_facet Cissy B. Kartasasmita
Sri Rezeki Hadinegoro
Nia Kurniati
Rina Triasih
Carolina Halim
Amgad Gamil
author_sort Cissy B. Kartasasmita
title Epidemiology, Nasopharyngeal Carriage, Serotype Prevalence, and Antibiotic Resistance of Streptococcus pneumoniae in Indonesia
title_short Epidemiology, Nasopharyngeal Carriage, Serotype Prevalence, and Antibiotic Resistance of Streptococcus pneumoniae in Indonesia
title_full Epidemiology, Nasopharyngeal Carriage, Serotype Prevalence, and Antibiotic Resistance of Streptococcus pneumoniae in Indonesia
title_fullStr Epidemiology, Nasopharyngeal Carriage, Serotype Prevalence, and Antibiotic Resistance of Streptococcus pneumoniae in Indonesia
title_full_unstemmed Epidemiology, Nasopharyngeal Carriage, Serotype Prevalence, and Antibiotic Resistance of Streptococcus pneumoniae in Indonesia
title_sort epidemiology, nasopharyngeal carriage, serotype prevalence, and antibiotic resistance of streptococcus pneumoniae in indonesia
publisher Adis, Springer Healthcare
series Infectious Diseases and Therapy
issn 2193-8229
2193-6382
publishDate 2020-08-01
description Abstract In Indonesia, pneumococcal disease represents a considerable public health concern; however, published data on the epidemiology, nasopharyngeal carriage, serotype prevalence, and antibiotic resistance of Streptococcus pneumoniae in this region are limited. Therefore, this article reviews the available data from a variety of sources and also summarizes pneumococcal conjugate vaccine implementation and recommendations in Indonesia and subsequent impact on pneumococcal disease. Regional pneumococcal vaccination recommendations in Asia were also reviewed. Studies showed that pneumococcal nasopharyngeal carriage prevalence in Indonesia was approximately 43% to 55% in healthy children aged less than 5 years, which varied by age group, region, and year. Serotype analysis of pneumococcal nasopharyngeal carriage isolates in Indonesia revealed that 38% to 60% of isolates would be covered by the 13-valent pneumococcal conjugate vaccine (PCV13). The antimicrobial resistance of pneumococcal disease has increased over time; between 1997 and 2012, resistance to penicillin and sulfamethoxazole increased from 0% to 28% and 9% to 62%, respectively. Inclusion of pneumococcal conjugate vaccines into immunization programs is being implemented gradually. In 2017, Indonesia implemented a regional PCV13 immunization program in Lombok with a 2 + 1 vaccination schedule that was expanded in 2018–2019 to West Nusa Tenggara and Bangka Belitung Provinces; this expansion is predicted to substantially reduce the burden of pneumococcal disease in Indonesia. Overall, the limited data available regarding pneumococcal disease in Indonesia highlight the unmet need for comprehensive disease surveillance studies in this region that can help direct vaccination strategies.
topic Antibiotic resistance
Indonesia
Nasopharyngeal carriage
Pneumococcal disease
Pneumococcal vaccination
url https://doi.org/10.1007/s40121-020-00330-5
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