A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice

A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice

TNFSF14 (LIGHT) contributes to airway inflammation and remodelling. Here the authors show that TNFSF14 acting on its receptor TNFRSF14 on mast cells enhances their IgE-dependent activation and that interference with this pathway attenuates features of asthma pathology in mice.

Bibliographic Details
Main Authors: Riccardo Sibilano, Nicolas Gaudenzio, Marianne K. DeGorter, Laurent L. Reber, Joseph D. Hernandez, Philipp M. Starkl, Oliwia W. Zurek, Mindy Tsai, Sonja Zahner, Stephen B. Montgomery, Axel Roers, Mitchell Kronenberg, Mang Yu, Stephen J. Galli
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13696

Internet

https://doi.org/10.1038/ncomms13696

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