Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction

Objective: To study the effect of nutritional support + intravenous chemotherapy on anti-tumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction. Methods: Patients with colon cancer complicated by incomplete intestinal obstructio...

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Main Authors: Yu-Fang Xie, Jian-Feng Guo
Format: Article
Language:English
Published: Editorial Board of Journal of Hainan Medical University 2018-07-01
Series:Journal of Hainan Medical University
Subjects:
Online Access:http://www.hnykdxxb.com/PDF/201813/22.pdf
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spelling doaj-9b93ed585bea4b82964c81ca2de26a062020-11-24T23:05:50ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372018-07-01248588Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstructionYu-Fang Xie0Jian-Feng Guo1Department of Cardiology, Midi Branch, Pangang Group General Hospital, Panzhihua 617063, Sichuan Province, China Digestive System, Medical Oncology Department, Midi Branch, Pangang Group General Hospital, Panzhihua 617063, Sichuan Province, ChinaObjective: To study the effect of nutritional support + intravenous chemotherapy on anti-tumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction. Methods: Patients with colon cancer complicated by incomplete intestinal obstruction who were treated in Midi Branch, Pangang Group General Hospital between March 2015 and October 2017 were selected and randomly divided into the nutrition group who accepted nutritional support + FOLFOX4 intravenous chemotherapy and the control group who accepted FOLFOX4 intravenous chemotherapy alone, and they underwent surgery after two cycles of chemotherapy. The contents of immune cells in peripheral blood and the contents of immune cytokines in serum were determined before chemotherapy and two cycles after chemotherapy; the expression levels of proliferation genes in colon cancer lesions were determined after surgical resection. Results: Compared with those of same group before chemotherapy, peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum IL-4, IL-9, IL-10, TGF-β1, IL-17 and IL-22 contents of nutrition group were decreased significantly after chemotherapywhereas peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum IL-4, IL-9, IL-10, TGF-β1, IL-17 and IL-22 contents of control group did not change significantly after chemotherapy, and compared with those after chemotherapy between groups, peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum IL-4, IL-9, IL- 10, TGF-β1, IL-17 and IL-22 contents of nutrition group were significantly lower than those of control group, and CyclinD1, Bcl-2, USP22, VEGF and N-cadherin mRNA expression were not different from those of control group. Conclusion: Nutritional support + intravenous chemotherapy can improve the anti-tumor immune response without affecting the proliferation of cancer cells in the lesion of patients with colon cancer complicated by incomplete intestinal obstruction.http://www.hnykdxxb.com/PDF/201813/22.pdf Colon cancerIncomplete intestinal obstructionNutritional supportAnti-tumor immune responseCell proliferation
collection DOAJ
language English
format Article
sources DOAJ
author Yu-Fang Xie
Jian-Feng Guo
spellingShingle Yu-Fang Xie
Jian-Feng Guo
Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction
Journal of Hainan Medical University
Colon cancer
Incomplete intestinal obstruction
Nutritional support
Anti-tumor immune response
Cell proliferation
author_facet Yu-Fang Xie
Jian-Feng Guo
author_sort Yu-Fang Xie
title Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction
title_short Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction
title_full Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction
title_fullStr Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction
title_full_unstemmed Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction
title_sort effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction
publisher Editorial Board of Journal of Hainan Medical University
series Journal of Hainan Medical University
issn 1007-1237
1007-1237
publishDate 2018-07-01
description Objective: To study the effect of nutritional support + intravenous chemotherapy on anti-tumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction. Methods: Patients with colon cancer complicated by incomplete intestinal obstruction who were treated in Midi Branch, Pangang Group General Hospital between March 2015 and October 2017 were selected and randomly divided into the nutrition group who accepted nutritional support + FOLFOX4 intravenous chemotherapy and the control group who accepted FOLFOX4 intravenous chemotherapy alone, and they underwent surgery after two cycles of chemotherapy. The contents of immune cells in peripheral blood and the contents of immune cytokines in serum were determined before chemotherapy and two cycles after chemotherapy; the expression levels of proliferation genes in colon cancer lesions were determined after surgical resection. Results: Compared with those of same group before chemotherapy, peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum IL-4, IL-9, IL-10, TGF-β1, IL-17 and IL-22 contents of nutrition group were decreased significantly after chemotherapywhereas peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum IL-4, IL-9, IL-10, TGF-β1, IL-17 and IL-22 contents of control group did not change significantly after chemotherapy, and compared with those after chemotherapy between groups, peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum IL-4, IL-9, IL- 10, TGF-β1, IL-17 and IL-22 contents of nutrition group were significantly lower than those of control group, and CyclinD1, Bcl-2, USP22, VEGF and N-cadherin mRNA expression were not different from those of control group. Conclusion: Nutritional support + intravenous chemotherapy can improve the anti-tumor immune response without affecting the proliferation of cancer cells in the lesion of patients with colon cancer complicated by incomplete intestinal obstruction.
topic Colon cancer
Incomplete intestinal obstruction
Nutritional support
Anti-tumor immune response
Cell proliferation
url http://www.hnykdxxb.com/PDF/201813/22.pdf
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