Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction
Objective: To study the effect of nutritional support + intravenous chemotherapy on anti-tumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction. Methods: Patients with colon cancer complicated by incomplete intestinal obstructio...
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doaj-9b93ed585bea4b82964c81ca2de26a062020-11-24T23:05:50ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372018-07-01248588Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstructionYu-Fang Xie0Jian-Feng Guo1Department of Cardiology, Midi Branch, Pangang Group General Hospital, Panzhihua 617063, Sichuan Province, China Digestive System, Medical Oncology Department, Midi Branch, Pangang Group General Hospital, Panzhihua 617063, Sichuan Province, ChinaObjective: To study the effect of nutritional support + intravenous chemotherapy on anti-tumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction. Methods: Patients with colon cancer complicated by incomplete intestinal obstruction who were treated in Midi Branch, Pangang Group General Hospital between March 2015 and October 2017 were selected and randomly divided into the nutrition group who accepted nutritional support + FOLFOX4 intravenous chemotherapy and the control group who accepted FOLFOX4 intravenous chemotherapy alone, and they underwent surgery after two cycles of chemotherapy. The contents of immune cells in peripheral blood and the contents of immune cytokines in serum were determined before chemotherapy and two cycles after chemotherapy; the expression levels of proliferation genes in colon cancer lesions were determined after surgical resection. Results: Compared with those of same group before chemotherapy, peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum IL-4, IL-9, IL-10, TGF-β1, IL-17 and IL-22 contents of nutrition group were decreased significantly after chemotherapywhereas peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum IL-4, IL-9, IL-10, TGF-β1, IL-17 and IL-22 contents of control group did not change significantly after chemotherapy, and compared with those after chemotherapy between groups, peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum IL-4, IL-9, IL- 10, TGF-β1, IL-17 and IL-22 contents of nutrition group were significantly lower than those of control group, and CyclinD1, Bcl-2, USP22, VEGF and N-cadherin mRNA expression were not different from those of control group. Conclusion: Nutritional support + intravenous chemotherapy can improve the anti-tumor immune response without affecting the proliferation of cancer cells in the lesion of patients with colon cancer complicated by incomplete intestinal obstruction.http://www.hnykdxxb.com/PDF/201813/22.pdf Colon cancerIncomplete intestinal obstructionNutritional supportAnti-tumor immune responseCell proliferation |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-Fang Xie Jian-Feng Guo |
spellingShingle |
Yu-Fang Xie Jian-Feng Guo Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction Journal of Hainan Medical University Colon cancer Incomplete intestinal obstruction Nutritional support Anti-tumor immune response Cell proliferation |
author_facet |
Yu-Fang Xie Jian-Feng Guo |
author_sort |
Yu-Fang Xie |
title |
Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction |
title_short |
Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction |
title_full |
Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction |
title_fullStr |
Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction |
title_full_unstemmed |
Effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction |
title_sort |
effect of nutritional support + intravenous chemotherapy on antitumor immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete intestinal obstruction |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2018-07-01 |
description |
Objective: To study the effect of nutritional support + intravenous chemotherapy on anti-tumor
immunity and cancer cell proliferation in patients with colon cancer complicated by incomplete
intestinal obstruction. Methods: Patients with colon cancer complicated by incomplete
intestinal obstruction who were treated in Midi Branch, Pangang Group General Hospital
between March 2015 and October 2017 were selected and randomly divided into the nutrition
group who accepted nutritional support + FOLFOX4 intravenous chemotherapy and the
control group who accepted FOLFOX4 intravenous chemotherapy alone, and they underwent
surgery after two cycles of chemotherapy. The contents of immune cells in peripheral blood
and the contents of immune cytokines in serum were determined before chemotherapy and
two cycles after chemotherapy; the expression levels of proliferation genes in colon cancer
lesions were determined after surgical resection. Results: Compared with those of same group
before chemotherapy, peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum
IL-4, IL-9, IL-10, TGF-β1, IL-17 and IL-22 contents of nutrition group were decreased
significantly after chemotherapywhereas peripheral blood Treg, Th9, Th17 and Th22 contents
as well as serum IL-4, IL-9, IL-10, TGF-β1, IL-17 and IL-22 contents of control group did not
change significantly after chemotherapy, and compared with those after chemotherapy between
groups, peripheral blood Treg, Th9, Th17 and Th22 contents as well as serum IL-4, IL-9, IL-
10, TGF-β1, IL-17 and IL-22 contents of nutrition group were significantly lower than those
of control group, and CyclinD1, Bcl-2, USP22, VEGF and N-cadherin mRNA expression
were not different from those of control group. Conclusion: Nutritional support + intravenous
chemotherapy can improve the anti-tumor immune response without affecting the proliferation
of cancer cells in the lesion of patients with colon cancer complicated by incomplete intestinal
obstruction. |
topic |
Colon cancer Incomplete intestinal obstruction Nutritional support Anti-tumor immune response Cell proliferation |
url |
http://www.hnykdxxb.com/PDF/201813/22.pdf |
work_keys_str_mv |
AT yufangxie effectofnutritionalsupportintravenouschemotherapyonantitumorimmunityandcancercellproliferationinpatientswithcoloncancercomplicatedbyincompleteintestinalobstruction AT jianfengguo effectofnutritionalsupportintravenouschemotherapyonantitumorimmunityandcancercellproliferationinpatientswithcoloncancercomplicatedbyincompleteintestinalobstruction |
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1725625520132980736 |