CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population.

CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population.

The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA4), a negative regulator of T lymphocytes, contains a single-nucleotide polymorphism (SNP) at position +6230A->G (ct60A->G), which has been found associated with several autoimmune diseases and appears to reduce T-cell inhibitory act...

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Main Authors: Thorsten Thye, Genevieve Scarisbrick, Edmund N L Browne, Margaret Amanua Chinbuah, John Gyapong, Ivy Osei, Ellis Owusu-Dabo, Stefan Niemann, Sabine Rüsch-Gerdes, Christian G Meyer, Rolf D Horstmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2707621?pdf=render

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http://europepmc.org/articles/PMC2707621?pdf=render

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