Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model
The bioavailability of curcumin from turmeric, Biocurcumax™ and as plain curcumin was investigated using conventional vehicles by a non-everted rat intestinal model. Results of ex vivo intestinal permeability studies showed an enhancement in the permeability of curcumin with increase in lipophilicit...
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doaj-9c59372f69954e9589f247ce415b412a2021-04-29T04:39:48ZengElsevierJournal of Functional Foods1756-46462010-01-01216065Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model Shishu0Manjul Maheshwari1Corresponding author: Tel.: +91 172 2534281 (O), +91 172 2782099 (R); fax: +91 172 2541142.; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaThe bioavailability of curcumin from turmeric, Biocurcumax™ and as plain curcumin was investigated using conventional vehicles by a non-everted rat intestinal model. Results of ex vivo intestinal permeability studies showed an enhancement in the permeability of curcumin with increase in lipophilicity of the vehicle used. Maximum permeability of curcumin was obtained from corn oil (13.4%) followed by clarified butter (9.82%), milk (4.24%) and aqueous suspension (1.66%) in 8 h. Another very interesting and important observation was that the permeation of curcumin was more from turmeric and Biocurcumax™ than from plain curcumin. These studies strongly suggest that curcumin may be consumed as turmeric/Biocurcumax™ in lipophilic vehicles instead of plain curcumin for maximum beneficial effects.http://www.sciencedirect.com/science/article/pii/S1756464610000058CurcuminPermeabilityNon-everted intestinal sacBiocurcumax™BioavailabilitySolubility |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shishu Manjul Maheshwari |
spellingShingle |
Shishu Manjul Maheshwari Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model Journal of Functional Foods Curcumin Permeability Non-everted intestinal sac Biocurcumax™ Bioavailability Solubility |
author_facet |
Shishu Manjul Maheshwari |
author_sort |
Shishu |
title |
Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model |
title_short |
Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model |
title_full |
Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model |
title_fullStr |
Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model |
title_full_unstemmed |
Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model |
title_sort |
comparative bioavailability of curcumin, turmeric and biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2010-01-01 |
description |
The bioavailability of curcumin from turmeric, Biocurcumax™ and as plain curcumin was investigated using conventional vehicles by a non-everted rat intestinal model. Results of ex vivo intestinal permeability studies showed an enhancement in the permeability of curcumin with increase in lipophilicity of the vehicle used. Maximum permeability of curcumin was obtained from corn oil (13.4%) followed by clarified butter (9.82%), milk (4.24%) and aqueous suspension (1.66%) in 8 h. Another very interesting and important observation was that the permeation of curcumin was more from turmeric and Biocurcumax™ than from plain curcumin. These studies strongly suggest that curcumin may be consumed as turmeric/Biocurcumax™ in lipophilic vehicles instead of plain curcumin for maximum beneficial effects. |
topic |
Curcumin Permeability Non-everted intestinal sac Biocurcumax™ Bioavailability Solubility |
url |
http://www.sciencedirect.com/science/article/pii/S1756464610000058 |
work_keys_str_mv |
AT shishu comparativebioavailabilityofcurcuminturmericandbiocurcumaxintraditionalvehiclesusingnonevertedratintestinalsacmodel AT manjulmaheshwari comparativebioavailabilityofcurcuminturmericandbiocurcumaxintraditionalvehiclesusingnonevertedratintestinalsacmodel |
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1721502182773096448 |