What Is New in Biomarker Testing at Diagnosis of Advanced Non-Squamous Non-Small Cell Lung Carcinoma? Implications for Cytology and Liquid Biopsy
The discovery and clinical validation of biomarkers predictive of the response of non-squamous non-small-cell lung carcinomas (NS-NSCLC) to therapeutic strategies continue to provide new data. The evaluation of novel treatments is based on molecular analyses aimed at determining their efficacy. Thes...
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doaj-9d6dc9b1d1dc4bd78352144a73cf072d2021-07-15T15:39:46ZengMDPI AGJournal of Molecular Pathology2673-52612021-06-0121514717210.3390/jmp2020015What Is New in Biomarker Testing at Diagnosis of Advanced Non-Squamous Non-Small Cell Lung Carcinoma? Implications for Cytology and Liquid BiopsyPaul Hofman0Laboratory of Clinical and Experimental Pathology, Université Côte d’Azur, CHU Nice, FHU OncoAge, Pasteur Hospital, 30 Avenue de la Voie Romaine, BP69, CEDEX 01, 06001 Nice, FranceThe discovery and clinical validation of biomarkers predictive of the response of non-squamous non-small-cell lung carcinomas (NS-NSCLC) to therapeutic strategies continue to provide new data. The evaluation of novel treatments is based on molecular analyses aimed at determining their efficacy. These tests are increasing in number, but the tissue specimens are smaller and smaller and/or can have few tumor cells. Indeed, in addition to tissue samples, complementary cytological and/or blood samples can also give access to these biomarkers. To date, it is recommended and necessary to look for the status of five genomic molecular biomarkers (<i>EGFR</i>, <i>ALK</i>, <i>ROS1</i>, <i>BRAFV600</i>, <i>NTRK</i>) and of a protein biomarker (PD-L1). However, the short- and more or less long-term emergence of new targeted treatments of genomic alterations on <i>RET</i> and <i>MET</i>, but also on others’ genomic alteration, notably on <i>KRAS</i>, <i>HER2</i>, <i>NRG1</i>, <i>SMARCA4</i>, and <i>NUT</i>, have made cellular and blood samples essential for molecular testing. The aim of this review is to present the interest in using cytological and/or liquid biopsies as complementary biological material, or as an alternative to tissue specimens, for detection at diagnosis of new predictive biomarkers of NS-NSCLC.https://www.mdpi.com/2673-5261/2/2/15lung cancerbiomarkerscytologyliquid biopsydiagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paul Hofman |
spellingShingle |
Paul Hofman What Is New in Biomarker Testing at Diagnosis of Advanced Non-Squamous Non-Small Cell Lung Carcinoma? Implications for Cytology and Liquid Biopsy Journal of Molecular Pathology lung cancer biomarkers cytology liquid biopsy diagnosis |
author_facet |
Paul Hofman |
author_sort |
Paul Hofman |
title |
What Is New in Biomarker Testing at Diagnosis of Advanced Non-Squamous Non-Small Cell Lung Carcinoma? Implications for Cytology and Liquid Biopsy |
title_short |
What Is New in Biomarker Testing at Diagnosis of Advanced Non-Squamous Non-Small Cell Lung Carcinoma? Implications for Cytology and Liquid Biopsy |
title_full |
What Is New in Biomarker Testing at Diagnosis of Advanced Non-Squamous Non-Small Cell Lung Carcinoma? Implications for Cytology and Liquid Biopsy |
title_fullStr |
What Is New in Biomarker Testing at Diagnosis of Advanced Non-Squamous Non-Small Cell Lung Carcinoma? Implications for Cytology and Liquid Biopsy |
title_full_unstemmed |
What Is New in Biomarker Testing at Diagnosis of Advanced Non-Squamous Non-Small Cell Lung Carcinoma? Implications for Cytology and Liquid Biopsy |
title_sort |
what is new in biomarker testing at diagnosis of advanced non-squamous non-small cell lung carcinoma? implications for cytology and liquid biopsy |
publisher |
MDPI AG |
series |
Journal of Molecular Pathology |
issn |
2673-5261 |
publishDate |
2021-06-01 |
description |
The discovery and clinical validation of biomarkers predictive of the response of non-squamous non-small-cell lung carcinomas (NS-NSCLC) to therapeutic strategies continue to provide new data. The evaluation of novel treatments is based on molecular analyses aimed at determining their efficacy. These tests are increasing in number, but the tissue specimens are smaller and smaller and/or can have few tumor cells. Indeed, in addition to tissue samples, complementary cytological and/or blood samples can also give access to these biomarkers. To date, it is recommended and necessary to look for the status of five genomic molecular biomarkers (<i>EGFR</i>, <i>ALK</i>, <i>ROS1</i>, <i>BRAFV600</i>, <i>NTRK</i>) and of a protein biomarker (PD-L1). However, the short- and more or less long-term emergence of new targeted treatments of genomic alterations on <i>RET</i> and <i>MET</i>, but also on others’ genomic alteration, notably on <i>KRAS</i>, <i>HER2</i>, <i>NRG1</i>, <i>SMARCA4</i>, and <i>NUT</i>, have made cellular and blood samples essential for molecular testing. The aim of this review is to present the interest in using cytological and/or liquid biopsies as complementary biological material, or as an alternative to tissue specimens, for detection at diagnosis of new predictive biomarkers of NS-NSCLC. |
topic |
lung cancer biomarkers cytology liquid biopsy diagnosis |
url |
https://www.mdpi.com/2673-5261/2/2/15 |
work_keys_str_mv |
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