Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens.

Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens.

Vaccinia virus (VACV) encodes an anti-apoptotic Bcl-2-like protein F1 that acts as an inhibitor of caspase-9 and of the Bak/Bax checkpoint but the role of this gene in immune responses is not known. Because dendritic cells that have phagocytosed apoptotic infected cells cross-present viral antigens...

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Bibliographic Details
Main Authors: Beatriz Perdiguero, Carmen Elena Gómez, Jose Luis Nájera, Carlos Oscar S Sorzano, Julie Delaloye, Rubén González-Sanz, Victoria Jiménez, Thierry Roger, Thierry Calandra, Giuseppe Pantaleo, Mariano Esteban
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23119046/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23119046/?tool=EBI

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