Lung Cancer Screening, towards a Multidimensional Approach: Why and How?
Early-stage treatment improves prognosis of lung cancer and two large randomized controlled trials have shown that early detection with low-dose computed tomography (LDCT) reduces mortality. Despite this, lung cancer screening (LCS) remains challenging. In the context of a global shortage of radiolo...
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doaj-9d7b70fc17fd4eb58e3b0e1b7cd5c4b02020-11-25T00:03:31ZengMDPI AGCancers2072-66942019-02-0111221210.3390/cancers11020212cancers11020212Lung Cancer Screening, towards a Multidimensional Approach: Why and How?Jonathan Benzaquen0Jacques Boutros1Charles Marquette2Hervé Delingette3Paul Hofman4Department of Pulmonary Medicine and Oncology, Université Côte d’Azur, CHU de Nice, FHU OncoAge, 06100 Nice, FranceDepartment of Pulmonary Medicine and Oncology, Université Côte d’Azur, CHU de Nice, FHU OncoAge, 06100 Nice, FranceDepartment of Pulmonary Medicine and Oncology, Université Côte d’Azur, CHU de Nice, FHU OncoAge, 06100 Nice, FranceAsclepios Project Team, Sophia Antipolis-Mediterranee Research Centre, Université Côte d’Azur, FHU OncoAge, Inria, 06902 Sophia Antipolis, FranceInstitute of Research on Cancer and Ageing (IRCAN), Université Côte d’Azur, FHU OncoAge, CNRS, INSERM, 06107 Nice, FranceEarly-stage treatment improves prognosis of lung cancer and two large randomized controlled trials have shown that early detection with low-dose computed tomography (LDCT) reduces mortality. Despite this, lung cancer screening (LCS) remains challenging. In the context of a global shortage of radiologists, the high rate of false-positive LDCT results in overloading of existing lung cancer clinics and multidisciplinary teams. Thus, to provide patients with earlier access to life-saving surgical interventions, there is an urgent need to improve LDCT-based LCS and especially to reduce the false-positive rate that plagues the current detection technology. In this context, LCS can be improved in three ways: (1) by refining selection criteria (risk factor assessment), (2) by using Computer Aided Diagnosis (CAD) to make it easier to interpret chest CTs, and (3) by using biological blood signatures for early cancer detection, to both spot the optimal target population and help classify lung nodules. These three main ways of improving LCS are discussed in this review.https://www.mdpi.com/2072-6694/11/2/212lung cancerartificial intelligencescreening |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jonathan Benzaquen Jacques Boutros Charles Marquette Hervé Delingette Paul Hofman |
spellingShingle |
Jonathan Benzaquen Jacques Boutros Charles Marquette Hervé Delingette Paul Hofman Lung Cancer Screening, towards a Multidimensional Approach: Why and How? Cancers lung cancer artificial intelligence screening |
author_facet |
Jonathan Benzaquen Jacques Boutros Charles Marquette Hervé Delingette Paul Hofman |
author_sort |
Jonathan Benzaquen |
title |
Lung Cancer Screening, towards a Multidimensional Approach: Why and How? |
title_short |
Lung Cancer Screening, towards a Multidimensional Approach: Why and How? |
title_full |
Lung Cancer Screening, towards a Multidimensional Approach: Why and How? |
title_fullStr |
Lung Cancer Screening, towards a Multidimensional Approach: Why and How? |
title_full_unstemmed |
Lung Cancer Screening, towards a Multidimensional Approach: Why and How? |
title_sort |
lung cancer screening, towards a multidimensional approach: why and how? |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2019-02-01 |
description |
Early-stage treatment improves prognosis of lung cancer and two large randomized controlled trials have shown that early detection with low-dose computed tomography (LDCT) reduces mortality. Despite this, lung cancer screening (LCS) remains challenging. In the context of a global shortage of radiologists, the high rate of false-positive LDCT results in overloading of existing lung cancer clinics and multidisciplinary teams. Thus, to provide patients with earlier access to life-saving surgical interventions, there is an urgent need to improve LDCT-based LCS and especially to reduce the false-positive rate that plagues the current detection technology. In this context, LCS can be improved in three ways: (1) by refining selection criteria (risk factor assessment), (2) by using Computer Aided Diagnosis (CAD) to make it easier to interpret chest CTs, and (3) by using biological blood signatures for early cancer detection, to both spot the optimal target population and help classify lung nodules. These three main ways of improving LCS are discussed in this review. |
topic |
lung cancer artificial intelligence screening |
url |
https://www.mdpi.com/2072-6694/11/2/212 |
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