IgA dominant postinfectious glomerulonephritis: Report of two cases

• Main Authors: V Rajakumar, S. A. K. Noor Mohamed, A A Kurien, M E Fernando
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2014-01-01
• Series: Indian Journal of Nephrology
• Subjects: Heavy proteinuria; immunoglobulin A dominant postinfectious glomerulonephritis; severe renal failure; unfavorable prognosis
• Online Access: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2014;volume=24;issue=3;spage=181;epage=184;aulast=Rajakumar

Immunoglobulin A (IgA) dominant postinfectious glomerulonephritis (IgA PIGN) is a distinct clinical entity increasingly recognized in adult. It usually presents with reduced glomerular filtration rate, heavy proteinuria, and has unfavorable prognosis. Immunofluorescence study of renal biopsy specimens have IgA as dominant or codominant antibody. We encountered two cases of IgA dominant PIGN recently presenting as rapidly progr essive glomerulonephritis and managed conservatively. Both the patients are on follow-up and do not have complete recovery of renal function till date. Long-term follow-up is needed to assess the progression of the disease in these patients.