An effective method to purify Plasmodium falciparum DNA directly from clinical blood samples for whole genome high-throughput sequencing.

Highly parallel sequencing technologies permit cost-effective whole genome sequencing of hundreds of Plasmodium parasites. The ability to sequence clinical Plasmodium samples, extracted directly from patient blood without a culture step, presents a unique opportunity to sample the diversity of "...

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Bibliographic Details
Main Authors: Sarah Auburn, Susana Campino, Taane G Clark, Abdoulaye A Djimde, Issaka Zongo, Robert Pinches, Magnus Manske, Valentina Mangano, Daniel Alcock, Elisa Anastasi, Gareth Maslen, Bronwyn Macinnis, Kirk Rockett, David Modiano, Christopher I Newbold, Ogobara K Doumbo, Jean Bosco Ouédraogo, Dominic P Kwiatkowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3138765?pdf=render