Case Report: Low Hematocrit Leading to Tacrolimus Toxicity

Case Report: Low Hematocrit Leading to Tacrolimus Toxicity

Tacrolimus is a calcineurin inhibitor characterized by a narrow therapeutic index and high intra- and inter-individual pharmacokinetic variability. Therapeutic drug monitoring in whole-blood is the standard monitoring procedure. However, tacrolimus extensively binds to erythrocytes, and tacrolimus w...

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Bibliographic Details
Main Authors: Alexandre Piletta-Zanin, Aurélie De Mul, Nathalie Rock, Pierre Lescuyer, Caroline F. Samer, Frédérique Rodieux
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
tacrolimus
monitoring
hematocrit
toxicity
subtherapeutic
pharmacokinetic
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.717148/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.717148/full

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