Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade

Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade

Monoclonal antibodies that target the inhibitory immune checkpoint axis consisting of programmed cell death protein 1 (PD-1) and its ligand, PD-L1, have changed the immune-oncology field. We identified K2, an anti-human PD-L1 single-domain antibody fragment, that can enhance T cell activation and tu...

Full description

Bibliographic Details
Main Authors: Robin Maximilian Awad, Quentin Lecocq, Katty Zeven, Thomas Ertveldt, Lien De Beck, Hannelore Ceuppens, Katrijn Broos, Yannick De Vlaeminck, Cleo Goyvaerts, Magali Verdonck, Geert Raes, Alexander Van Parys, Anje Cauwels, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
programmed death-ligand 1
single domain antibody
nanobody
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001017

Internet

http://www.sciencedirect.com/science/article/pii/S2329050121001017

Similar Items