A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran
OBJECTIVES Toxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of Toxoplasma gondii among patients undergoing hemodialysis in Iran. METHODS...
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Korean Society of Epidemiology
2018-04-01
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doaj-a0305a7a66c54132b7b91431984bf1d42020-11-25T01:34:21ZengKorean Society of Epidemiology Epidemiology and Health2092-71932018-04-014010.4178/epih.e2018016969A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in IranMasoud Foroutan0Ali Rostami1Hamidreza Majidiani2Seyed Mohammad Riahi3Sasan Khazaei4Milad Badri5Elham Yousefi6 Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranOBJECTIVES Toxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of Toxoplasma gondii among patients undergoing hemodialysis in Iran. METHODS We searched English and Persian databases for studies reporting T. gondii seroprevalence in Iranian hemodialysis patients through December 31, 2017. Inclusion and exclusion criteria were applied. RESULTS A total of 10 studies containing 1,865 participants (1,048 patients and 817 controls) met the eligibility criteria. Immunoglobulin G (IgG) antibodies against T. gondii were found in 58% (95% confidence interval [CI], 46 to 70) of hemodialysis patients and 40% (95% CI, 31 to 50) of healthy controls, while immunoglobulin M (IgM) antibodies were found in 2% (95% CI, 0 to 6) of hemodialysis patients and 0% (95% CI, 0 to 1) of healthy controls. The meta-analysis showed that hemodialysis patients were significantly more likely to be seropositive for IgG (odds ratio [OR], 2.04; 95% CI, 1.54 to 2.70; p<0.001) and IgM (OR, 2.53; 95% CI, 1.23 to 5.22; p<0.001) antibodies against T. gondii infection than healthy individuals. CONCLUSIONS The current study revealed a high prevalence of T. gondii infection in hemodialysis patients. Since hemodialysis patients are immunocompromised and T. gondii can cause serious clinical complications, we recommend that periodic screenings for T. gondii infection should be incorporated into the routine clinical care of these patients.http://www.e-epih.org/upload/pdf/epih-40-e2018016.pdfSeroprevalenceHemodialysis patientsIran |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masoud Foroutan Ali Rostami Hamidreza Majidiani Seyed Mohammad Riahi Sasan Khazaei Milad Badri Elham Yousefi |
spellingShingle |
Masoud Foroutan Ali Rostami Hamidreza Majidiani Seyed Mohammad Riahi Sasan Khazaei Milad Badri Elham Yousefi A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran Epidemiology and Health Seroprevalence Hemodialysis patients Iran |
author_facet |
Masoud Foroutan Ali Rostami Hamidreza Majidiani Seyed Mohammad Riahi Sasan Khazaei Milad Badri Elham Yousefi |
author_sort |
Masoud Foroutan |
title |
A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran |
title_short |
A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran |
title_full |
A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran |
title_fullStr |
A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran |
title_full_unstemmed |
A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran |
title_sort |
systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in iran |
publisher |
Korean Society of Epidemiology |
series |
Epidemiology and Health |
issn |
2092-7193 |
publishDate |
2018-04-01 |
description |
OBJECTIVES Toxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of Toxoplasma gondii among patients undergoing hemodialysis in Iran. METHODS We searched English and Persian databases for studies reporting T. gondii seroprevalence in Iranian hemodialysis patients through December 31, 2017. Inclusion and exclusion criteria were applied. RESULTS A total of 10 studies containing 1,865 participants (1,048 patients and 817 controls) met the eligibility criteria. Immunoglobulin G (IgG) antibodies against T. gondii were found in 58% (95% confidence interval [CI], 46 to 70) of hemodialysis patients and 40% (95% CI, 31 to 50) of healthy controls, while immunoglobulin M (IgM) antibodies were found in 2% (95% CI, 0 to 6) of hemodialysis patients and 0% (95% CI, 0 to 1) of healthy controls. The meta-analysis showed that hemodialysis patients were significantly more likely to be seropositive for IgG (odds ratio [OR], 2.04; 95% CI, 1.54 to 2.70; p<0.001) and IgM (OR, 2.53; 95% CI, 1.23 to 5.22; p<0.001) antibodies against T. gondii infection than healthy individuals. CONCLUSIONS The current study revealed a high prevalence of T. gondii infection in hemodialysis patients. Since hemodialysis patients are immunocompromised and T. gondii can cause serious clinical complications, we recommend that periodic screenings for T. gondii infection should be incorporated into the routine clinical care of these patients. |
topic |
Seroprevalence Hemodialysis patients Iran |
url |
http://www.e-epih.org/upload/pdf/epih-40-e2018016.pdf |
work_keys_str_mv |
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