Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb
Local field potential oscillations reflect temporally coordinated neuronal ensembles—coupling distant brain regions, gating processing windows, and providing a reference for spike timing-based codes. In phase amplitude coupling (PAC), the amplitude of the envelope of a faster oscillation is larger w...
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doaj-a030c5067e2442af8f319a190185bce32021-05-05T20:46:48ZengeLife Sciences Publications LtdeLife2050-084X2020-01-01910.7554/eLife.52583Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulbJustin Losacco0Daniel Ramirez-Gordillo1https://orcid.org/0000-0002-8189-6069Jesse Gilmer2https://orcid.org/0000-0001-5778-1061Diego Restrepo3https://orcid.org/0000-0002-4972-446XNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, United States; Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United StatesNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, United States; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, United StatesNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, United States; Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United StatesLocal field potential oscillations reflect temporally coordinated neuronal ensembles—coupling distant brain regions, gating processing windows, and providing a reference for spike timing-based codes. In phase amplitude coupling (PAC), the amplitude of the envelope of a faster oscillation is larger within a phase window of a slower carrier wave. Here, we characterized PAC, and the related theta phase-referenced high gamma and beta power (PRP), in the olfactory bulb of mice learning to discriminate odorants. PAC changes throughout learning, and odorant-elicited changes in PRP increase for rewarded and decrease for unrewarded odorants. Contextual odorant identity (is the odorant rewarded?) can be decoded from peak PRP in animals proficient in odorant discrimination, but not in naïve mice. As the animal learns to discriminate the odorants the dimensionality of PRP decreases. Therefore, modulation of phase-referenced chunking of information in the course of learning plays a role in early sensory processing in olfaction.https://elifesciences.org/articles/52583olfactionphase amplitude couplinglocal field potentialdimensionalityassociative learningbehavior |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Justin Losacco Daniel Ramirez-Gordillo Jesse Gilmer Diego Restrepo |
spellingShingle |
Justin Losacco Daniel Ramirez-Gordillo Jesse Gilmer Diego Restrepo Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb eLife olfaction phase amplitude coupling local field potential dimensionality associative learning behavior |
author_facet |
Justin Losacco Daniel Ramirez-Gordillo Jesse Gilmer Diego Restrepo |
author_sort |
Justin Losacco |
title |
Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb |
title_short |
Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb |
title_full |
Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb |
title_fullStr |
Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb |
title_full_unstemmed |
Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb |
title_sort |
learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2020-01-01 |
description |
Local field potential oscillations reflect temporally coordinated neuronal ensembles—coupling distant brain regions, gating processing windows, and providing a reference for spike timing-based codes. In phase amplitude coupling (PAC), the amplitude of the envelope of a faster oscillation is larger within a phase window of a slower carrier wave. Here, we characterized PAC, and the related theta phase-referenced high gamma and beta power (PRP), in the olfactory bulb of mice learning to discriminate odorants. PAC changes throughout learning, and odorant-elicited changes in PRP increase for rewarded and decrease for unrewarded odorants. Contextual odorant identity (is the odorant rewarded?) can be decoded from peak PRP in animals proficient in odorant discrimination, but not in naïve mice. As the animal learns to discriminate the odorants the dimensionality of PRP decreases. Therefore, modulation of phase-referenced chunking of information in the course of learning plays a role in early sensory processing in olfaction. |
topic |
olfaction phase amplitude coupling local field potential dimensionality associative learning behavior |
url |
https://elifesciences.org/articles/52583 |
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