Actual long-term survival after resection of stage III soft tissue sarcoma

Abstract Background Actuarial survival based on the Kaplan–Meier method can overestimate actual long-term survival, especially among those with factors of poor prognosis. Patients with American Joint Committee on Cancer stage III soft tissue sarcoma (STS) represent a subset with a high risk of STS-s...

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Main Authors: Do Weon Lee, Han-Soo Kim, Ilkyu Han
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12885-020-07730-3
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spelling doaj-a03d02b2d1d442e096260ac3925b68bb2021-01-10T12:59:42ZengBMCBMC Cancer1471-24072021-01-012111810.1186/s12885-020-07730-3Actual long-term survival after resection of stage III soft tissue sarcomaDo Weon Lee0Han-Soo Kim1Ilkyu Han2Department of Orthopaedic Surgery, Seoul National University HospitalDepartment of Orthopaedic Surgery, Seoul National University HospitalDepartment of Orthopaedic Surgery, Seoul National University HospitalAbstract Background Actuarial survival based on the Kaplan–Meier method can overestimate actual long-term survival, especially among those with factors of poor prognosis. Patients with American Joint Committee on Cancer stage III soft tissue sarcoma (STS) represent a subset with a high risk of STS-specific mortality. Therefore, we aimed to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III STS. Methods We retrospectively reviewed 116 patients who underwent surgical resection for stage III STS with curative intent between March 2000 and December 2013. Long-term survivors (n = 61), defined as those who survived beyond 5 years, were compared with short-term survivors (n = 36), who died of STS within 5 years. Results Multivariate logistic regression analyses showed that a tumor size < 10 cm [odds ratio (OR) 3.95, p = 0.047], histological grade of 2 (OR 8.12, p = 0.004), and American Society of Anesthesiologists (ASA) score of 1 (OR 11.25, p = 0.001) were independently associated with actual 5-year survival. However, 66% of the long-term survivors exhibited factors of poor prognosis: 36% had a tumor size > 10 cm and 48% had a histological grade of 3. Leiomyosarcoma (3 of 10) was negatively associated with actual long-term survival. Conclusions Actual 5-year survival after resection of stage III STS was associated with tumor size, histological grade, and ASA score. However, majority of the actual 5-year survivors exhibit factors of poor prognosis, suggesting that aggressive treatment should be offered for a chance of long-term survival in these patients.https://doi.org/10.1186/s12885-020-07730-3SarcomaSoft tissue sarcomaSurvival
collection DOAJ
language English
format Article
sources DOAJ
author Do Weon Lee
Han-Soo Kim
Ilkyu Han
spellingShingle Do Weon Lee
Han-Soo Kim
Ilkyu Han
Actual long-term survival after resection of stage III soft tissue sarcoma
BMC Cancer
Sarcoma
Soft tissue sarcoma
Survival
author_facet Do Weon Lee
Han-Soo Kim
Ilkyu Han
author_sort Do Weon Lee
title Actual long-term survival after resection of stage III soft tissue sarcoma
title_short Actual long-term survival after resection of stage III soft tissue sarcoma
title_full Actual long-term survival after resection of stage III soft tissue sarcoma
title_fullStr Actual long-term survival after resection of stage III soft tissue sarcoma
title_full_unstemmed Actual long-term survival after resection of stage III soft tissue sarcoma
title_sort actual long-term survival after resection of stage iii soft tissue sarcoma
publisher BMC
series BMC Cancer
issn 1471-2407
publishDate 2021-01-01
description Abstract Background Actuarial survival based on the Kaplan–Meier method can overestimate actual long-term survival, especially among those with factors of poor prognosis. Patients with American Joint Committee on Cancer stage III soft tissue sarcoma (STS) represent a subset with a high risk of STS-specific mortality. Therefore, we aimed to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III STS. Methods We retrospectively reviewed 116 patients who underwent surgical resection for stage III STS with curative intent between March 2000 and December 2013. Long-term survivors (n = 61), defined as those who survived beyond 5 years, were compared with short-term survivors (n = 36), who died of STS within 5 years. Results Multivariate logistic regression analyses showed that a tumor size < 10 cm [odds ratio (OR) 3.95, p = 0.047], histological grade of 2 (OR 8.12, p = 0.004), and American Society of Anesthesiologists (ASA) score of 1 (OR 11.25, p = 0.001) were independently associated with actual 5-year survival. However, 66% of the long-term survivors exhibited factors of poor prognosis: 36% had a tumor size > 10 cm and 48% had a histological grade of 3. Leiomyosarcoma (3 of 10) was negatively associated with actual long-term survival. Conclusions Actual 5-year survival after resection of stage III STS was associated with tumor size, histological grade, and ASA score. However, majority of the actual 5-year survivors exhibit factors of poor prognosis, suggesting that aggressive treatment should be offered for a chance of long-term survival in these patients.
topic Sarcoma
Soft tissue sarcoma
Survival
url https://doi.org/10.1186/s12885-020-07730-3
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