Parkinson’s disease psychosis
Rebekah J Jakel,1,2 Mark Stacy31Department of Psychiatry, Duke University, Durham, NC, USA; 2Durham Veteran's Administration Medical Center, Durham, NC, USA; 3Department of Neurology, Duke University, Durham, NC, USAAbstract: Parkinson’s disease is a progressive neurodegenerative...
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2014-03-01
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Online Access: | http://www.dovepress.com/parkinsonrsquos-disease-psychosis-a16242 |
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doaj-a03ea74d39e54b82b8d6cecf971341442020-11-24T22:45:17ZengDove Medical PressJournal of Parkinsonism and Restless Legs Syndrome1927-77332014-03-012014default415116242Parkinson’s disease psychosisJakel RJStacy M Rebekah J Jakel,1,2 Mark Stacy31Department of Psychiatry, Duke University, Durham, NC, USA; 2Durham Veteran's Administration Medical Center, Durham, NC, USA; 3Department of Neurology, Duke University, Durham, NC, USAAbstract: Parkinson’s disease is a progressive neurodegenerative disease characterized by loss of nigral dopaminergic neurons associated with rigidity, resting tremor, bradykinesia, and postural instability. In addition to the above motor symptoms, nonmotor manifestations are increasingly recognized as part of Parkinson's disease pathology and contribute to overall symptom burden, morbidity, and mortality. Such nonmotor symptoms include autonomic dysfunction, impaired olfaction, gastrointestinal disturbances, and a variety of psychiatric symptoms including psychosis. Psychiatric symptoms may be inherent to the disease process itself, secondary to treatments aimed at restoring dopamine, or related to comorbid mental illness. Given that traditional medications used to treat psychosis are dopaminergic antagonists, pharmacologic treatment of these symptoms carries the risk of worsening the movement disorder, creating a challenge for providers. This review examines current literature regarding psychosis in the context of Parkinson’s disease including risk factors for psychosis, prognosis, and management of these challenging symptoms.Keywords: antipsychotics, delusions, hallucinations, non-motor symptoms, paranoiahttp://www.dovepress.com/parkinsonrsquos-disease-psychosis-a16242 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jakel RJ Stacy M |
spellingShingle |
Jakel RJ Stacy M Parkinson’s disease psychosis Journal of Parkinsonism and Restless Legs Syndrome |
author_facet |
Jakel RJ Stacy M |
author_sort |
Jakel RJ |
title |
Parkinson’s disease psychosis |
title_short |
Parkinson’s disease psychosis |
title_full |
Parkinson’s disease psychosis |
title_fullStr |
Parkinson’s disease psychosis |
title_full_unstemmed |
Parkinson’s disease psychosis |
title_sort |
parkinson’s disease psychosis |
publisher |
Dove Medical Press |
series |
Journal of Parkinsonism and Restless Legs Syndrome |
issn |
1927-7733 |
publishDate |
2014-03-01 |
description |
Rebekah J Jakel,1,2 Mark Stacy31Department of Psychiatry, Duke University, Durham, NC, USA; 2Durham Veteran's Administration Medical Center, Durham, NC, USA; 3Department of Neurology, Duke University, Durham, NC, USAAbstract: Parkinson’s disease is a progressive neurodegenerative disease characterized by loss of nigral dopaminergic neurons associated with rigidity, resting tremor, bradykinesia, and postural instability. In addition to the above motor symptoms, nonmotor manifestations are increasingly recognized as part of Parkinson's disease pathology and contribute to overall symptom burden, morbidity, and mortality. Such nonmotor symptoms include autonomic dysfunction, impaired olfaction, gastrointestinal disturbances, and a variety of psychiatric symptoms including psychosis. Psychiatric symptoms may be inherent to the disease process itself, secondary to treatments aimed at restoring dopamine, or related to comorbid mental illness. Given that traditional medications used to treat psychosis are dopaminergic antagonists, pharmacologic treatment of these symptoms carries the risk of worsening the movement disorder, creating a challenge for providers. This review examines current literature regarding psychosis in the context of Parkinson’s disease including risk factors for psychosis, prognosis, and management of these challenging symptoms.Keywords: antipsychotics, delusions, hallucinations, non-motor symptoms, paranoia |
url |
http://www.dovepress.com/parkinsonrsquos-disease-psychosis-a16242 |
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AT jakelrj parkinsonrsquosdiseasepsychosis AT stacym parkinsonrsquosdiseasepsychosis |
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