Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways

Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways

Osteoclasts with elevated bone resorption are commonly present in postmenopausal osteoporosis, and other osteolytic pathologies. Therefore, suppressing osteoclast generation and function has been the main focus of osteoporosis treatment. Betulinic acid (BA) represents a triterpenoid mainly purified...

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Bibliographic Details
Main Authors: Jiyong Wei, Yicheng Li, Qian Liu, Yanni Lan, Chengming Wei, Kun Tian, Liwei Wu, Chunbo Lin, Jiake Xu, Jinmin Zhao, Yuan Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
betulinic acid
osteoclast
receptor activator of nuclear factor‐κB ligand
osteoporosis
MAPK
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01025/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.01025/full

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