Involvement of the pulmonary arteries in patients with Takayasu arteritis: a prospective study from a single centre in China
Abstract Background Takayasu arteritis (TA) is a large vessel vasculitis that can involve pulmonary arteries (PAs). We studied multiple clinical characteristics related to pulmonary artery involvement (PAI) in TA patients. Methods We enrolled 216 patients with TA from a large prospective cohort. PAI...
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doaj-a0ea78a6cfc54b868356765f8c7ae52e2020-11-25T03:31:23ZengBMCArthritis Research & Therapy1478-63622020-06-0122111010.1186/s13075-020-02203-1Involvement of the pulmonary arteries in patients with Takayasu arteritis: a prospective study from a single centre in ChinaXiufang Kong0Lili Ma1Peng Lv2Xiaomeng Cui3Rongyi Chen4Zongfei Ji5Huiyong Chen6Jiang Lin7Lindi Jiang8Department of Rheumatology, Zhongshan Hospital Affiliated to Fudan UniversityDepartment of Rheumatology, Zhongshan Hospital Affiliated to Fudan UniversityDepartment of Radiology, Zhongshan Hospital Affiliated to Fudan UniversityDepartment of Rheumatology, Zhongshan Hospital Affiliated to Fudan UniversityDepartment of Rheumatology, Zhongshan Hospital Affiliated to Fudan UniversityDepartment of Rheumatology, Zhongshan Hospital Affiliated to Fudan UniversityDepartment of Rheumatology, Zhongshan Hospital Affiliated to Fudan UniversityDepartment of Radiology, Zhongshan Hospital Affiliated to Fudan UniversityDepartment of Rheumatology, Zhongshan Hospital Affiliated to Fudan UniversityAbstract Background Takayasu arteritis (TA) is a large vessel vasculitis that can involve pulmonary arteries (PAs). We studied multiple clinical characteristics related to pulmonary artery involvement (PAI) in TA patients. Methods We enrolled 216 patients with TA from a large prospective cohort. PAI was assessed in each patient based on data from magnetic resonance angiography/computed tomography angiography. Pulmonary hypertension, cardiac function, and pulmonary parenchymal lesions were evaluated further in patients with PAI based on echocardiography, the New York Heart Association Functional Classification, and pulmonary computed tomography, respectively. These abnormalities related to PAI were followed up to evaluate treatment effects. Results PAI was detected in 56/216 (25.93%) patients, which involved the pulmonary trunk, main PAs, and small vessels in the lungs. Among patients with PAI, 28 (50%) patients were accompanied by pulmonary hypertension, which was graded as ‘severe’ in 9 (16.07%), ‘moderate’ in 10 (17.86%), and mild in 9 (16.07%). Twenty-six (46.43%) patients showed advanced NYHA function (III, 20, 35.71%; IV, 6, 10.71%). Furthermore, 21 (37.50%) patients presented with abnormal pulmonary parenchymal lesions in the area corresponding to PAI (e.g. the mosaic sign, infarction, bronchiectasis). During follow-up, two patients died due to heart failure and pulmonary thrombosis. In the remaining patients, the abnormalities mentioned above improved partially after routine treatment. Conclusions PAI is common in TA patients. PAI can cause pulmonary hypertension, cardiac insufficiency, and pulmonary parenchymal lesions, which worsen patients’ prognosis.http://link.springer.com/article/10.1186/s13075-020-02203-1Takayasu arteritisPulmonary artery involvementCardiac functionPulmonary lesions |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiufang Kong Lili Ma Peng Lv Xiaomeng Cui Rongyi Chen Zongfei Ji Huiyong Chen Jiang Lin Lindi Jiang |
spellingShingle |
Xiufang Kong Lili Ma Peng Lv Xiaomeng Cui Rongyi Chen Zongfei Ji Huiyong Chen Jiang Lin Lindi Jiang Involvement of the pulmonary arteries in patients with Takayasu arteritis: a prospective study from a single centre in China Arthritis Research & Therapy Takayasu arteritis Pulmonary artery involvement Cardiac function Pulmonary lesions |
author_facet |
Xiufang Kong Lili Ma Peng Lv Xiaomeng Cui Rongyi Chen Zongfei Ji Huiyong Chen Jiang Lin Lindi Jiang |
author_sort |
Xiufang Kong |
title |
Involvement of the pulmonary arteries in patients with Takayasu arteritis: a prospective study from a single centre in China |
title_short |
Involvement of the pulmonary arteries in patients with Takayasu arteritis: a prospective study from a single centre in China |
title_full |
Involvement of the pulmonary arteries in patients with Takayasu arteritis: a prospective study from a single centre in China |
title_fullStr |
Involvement of the pulmonary arteries in patients with Takayasu arteritis: a prospective study from a single centre in China |
title_full_unstemmed |
Involvement of the pulmonary arteries in patients with Takayasu arteritis: a prospective study from a single centre in China |
title_sort |
involvement of the pulmonary arteries in patients with takayasu arteritis: a prospective study from a single centre in china |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2020-06-01 |
description |
Abstract Background Takayasu arteritis (TA) is a large vessel vasculitis that can involve pulmonary arteries (PAs). We studied multiple clinical characteristics related to pulmonary artery involvement (PAI) in TA patients. Methods We enrolled 216 patients with TA from a large prospective cohort. PAI was assessed in each patient based on data from magnetic resonance angiography/computed tomography angiography. Pulmonary hypertension, cardiac function, and pulmonary parenchymal lesions were evaluated further in patients with PAI based on echocardiography, the New York Heart Association Functional Classification, and pulmonary computed tomography, respectively. These abnormalities related to PAI were followed up to evaluate treatment effects. Results PAI was detected in 56/216 (25.93%) patients, which involved the pulmonary trunk, main PAs, and small vessels in the lungs. Among patients with PAI, 28 (50%) patients were accompanied by pulmonary hypertension, which was graded as ‘severe’ in 9 (16.07%), ‘moderate’ in 10 (17.86%), and mild in 9 (16.07%). Twenty-six (46.43%) patients showed advanced NYHA function (III, 20, 35.71%; IV, 6, 10.71%). Furthermore, 21 (37.50%) patients presented with abnormal pulmonary parenchymal lesions in the area corresponding to PAI (e.g. the mosaic sign, infarction, bronchiectasis). During follow-up, two patients died due to heart failure and pulmonary thrombosis. In the remaining patients, the abnormalities mentioned above improved partially after routine treatment. Conclusions PAI is common in TA patients. PAI can cause pulmonary hypertension, cardiac insufficiency, and pulmonary parenchymal lesions, which worsen patients’ prognosis. |
topic |
Takayasu arteritis Pulmonary artery involvement Cardiac function Pulmonary lesions |
url |
http://link.springer.com/article/10.1186/s13075-020-02203-1 |
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