Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin A), which interact weakly with capsids. Efficient capsid recognition al...

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Bibliographic Details
Main Authors: Yen-Li Li, Viswanathan Chandrasekaran, Stephen D Carter, Cora L Woodward, Devin E Christensen, Kelly A Dryden, Owen Pornillos, Mark Yeager, Barbie K Ganser-Pornillos, Grant J Jensen, Wesley I Sundquist
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
TRIM5
HIV-1
capsid
hexagonal assembly
restriction
Online Access:https://elifesciences.org/articles/16269

Internet

https://elifesciences.org/articles/16269

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