Effects of Structural Isomers of Spermine on the Higher-Order Structure of DNA and Gene Expression

Effects of Structural Isomers of Spermine on the Higher-Order Structure of DNA and Gene Expression

Polyamines are involved in various biological functions, including cell proliferation, differentiation, gene regulation, etc. Recently, it was found that polyamines exhibit biphasic effects on gene expression: promotion and inhibition at low and high concentrations, respectively. Here, we compared t...

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Bibliographic Details
Main Authors: Tomoki Kitagawa, Takashi Nishio, Yuko Yoshikawa, Naoki Umezawa, Tsunehiko Higuchi, Chwen-Yang Shew, Takahiro Kenmotsu, Kenichi Yoshikawa
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
polyamine
higher-order structure of DNA
gene expression
bimodal effect of promotion and inhibition
Online Access:https://www.mdpi.com/1422-0067/22/5/2355

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https://www.mdpi.com/1422-0067/22/5/2355

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