Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models

Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models

Cardiovascular disease-related deaths frequently arise from arrhythmias, but treatment options are limited due to perilous side effects of commonly used antiarrhythmic drugs. Cardiac rhythmicity strongly depends on cardiomyocyte Ca2+ handling and prevalent cardiac diseases are causally associated wi...

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Bibliographic Details
Main Authors: Maria K. Schweitzer, MSc, Fabiola Wilting, MSc, Simon Sedej, PhD, Lisa Dreizehnter, PhD, Nathan J. Dupper, BSc, Qinghai Tian, PhD, Alessandra Moretti, PhD, Ilaria My, MD, Ohyun Kwon, PhD, Silvia G. Priori, MD, PhD, Karl-Ludwig Laugwitz, MD, Ursula Storch, PhD, Peter Lipp, PhD, Andreas Breit, PhD, Michael Mederos y Schnitzler, PhD, Thomas Gudermann, MD, Johann Schredelseker, PhD
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:JACC: Basic to Translational Science
Subjects:
CPVT
MCU
MiCUp
mitochondria
RyR2
VDAC2
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17301584

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http://www.sciencedirect.com/science/article/pii/S2452302X17301584

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