Plasma Extracellular Vesicles Enhance HIV-1 Infection of Activated CD4+ T Cells and Promote the Activation of Latently Infected J-Lat10.6 Cells via miR-139-5p Transfer

Plasma Extracellular Vesicles Enhance HIV-1 Infection of Activated CD4+ T Cells and Promote the Activation of Latently Infected J-Lat10.6 Cells via miR-139-5p Transfer

HIV latency is a challenge to the success of antiretroviral therapy (ART). Hence patients may benefit from interventions that efficiently reactivate the latent virus to be eliminated by ARTs. Here we show that plasma extracellular vesicles (pEVs) can enhance HIV infection of activated CD4+ T cells a...

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Bibliographic Details
Main Authors: Isobel Okoye, Lai Xu, Olaide Oyegbami, Shima Shahbaz, Desmond Pink, Priscilla Gao, Xuejun Sun, Shokrollah Elahi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
HIV
extracellular vehicles (EVs)
HIV latency
CD4+ T cells
microRNAs
T cell activation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.697604/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.697604/full

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