Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology

Objective To analyze the parameters that predict the surgical margin positivity after radical prostatectomy for localized prostate cancer. Materials and Methods In this multicenter study, the data of 1607 consecutive patients undergoing radical prostatectomy for localized prostate cancer in 12...

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Main Authors: Deniz Bolat, Saadettin Eskiçorapcı, Erdem Karabulut, Sümer Baltacı, Asıf Yıldırım, Sinan Sözen, Ferhat Ateş, Çağrı Akın Şekerci, Fatih Kurtuluş, Ayhan Dirim, Talha Muezzioğlu, Cavit Can1, Murat Bozlu, Hakan Gemalmaz, Sinan Ekici1, Haluk Özen, Levent Turkeri
Format: Article
Language:English
Published: Galenos Yayinevi 2015-03-01
Series:Journal of Urological Surgery
Subjects:
PSA
Online Access:http://jurolsurgery.org/article_8777/Can-We-Predict-The-Surgical-Margin-Positivity-In-Patients-Treated-With-Radical-Prostatectomy-A-Multicenter-Cohort-Of-Turkish-Association-Of-Uro-oncology
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spelling doaj-a218452c70b54ea1ae7612486aadfd382020-11-25T01:47:12ZengGalenos YayineviJournal of Urological Surgery2148-95802015-03-012171210.4274/jus.220Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-OncologyDeniz Bolat0Saadettin Eskiçorapcı1Erdem Karabulut2Sümer Baltacı3Asıf Yıldırım4Sinan Sözen5Ferhat Ateş6Çağrı Akın Şekerci7Fatih Kurtuluş8Ayhan Dirim9Talha Muezzioğlu10 Cavit Can111Murat Bozlu12Hakan Gemalmaz13Sinan Ekici114Haluk Özen15Levent Turkeri16İzmir Bozyaka Training and Research Hospital, Clinic of Urology, İzmir, Turkeyİzmir Bozyaka Training and Research Hospital, Clinic of Urology, İzmir, TurkeyHacettepe University Faculty of Medicine, Department of Biostatistics, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Urology, Ankara, TurkeyMedeniyet University Göztepe Training and Research Hospital, Clinic of Urology, İstanbul, TurkeyGazi University Faculty of Medicine, Department of Urology, Ankara, TurkeyGATA Haydarpaşa Training Hospital, Clinic of Urology, İstanbul, TurkeyMarmara University Faculty of Medicine , Department of Urology, İstanbul, TurkeyKemerburgaz University Faculty of Medicine, Department of Urology, İstanbul, TurkeyBaskent University Faculty of Medicine, Department of Urology, Ankara, TurkeyCelal Bayar University Faculty of Medicine, Department of Urology, Manisa, TurkeyOsman Gazi University Faculty of Medicine, Department of Urology, Eskisehir, TurkeyMersin University Faculty of Medicine, Department of Urology, Mersin, TurkeyAdnan Menderes University Faculty of Medicine, Department of Urology, Aydin, TurkeyMaltepe University Faculty of Medicine, Department of Urology, İstanbul, TurkeyHacettepe University Faculty of Medicine, Department of Urology, Ankara, TurkeyMarmara University Faculty of Medicine, Department of Urology, İstanbul, TurkeyObjective To analyze the parameters that predict the surgical margin positivity after radical prostatectomy for localized prostate cancer. Materials and Methods In this multicenter study, the data of 1607 consecutive patients undergoing radical prostatectomy for localized prostate cancer in 12 different clinics in Turkey between 1993-2011 were assessed. Patients who had neoadjuvant treatment were excluded. We assessed the relationship between potential predictive factors and surgical margin status after radical prostatectomy such as age, cancer characteristics, history of transurethral prostate resection, surgical experience and nerve-sparing technique by using univariate and multivariate Cox regression analyses and t test. Results The overall surgical margin positivity rate was 22.6% (359 patients). In univariate analyses, preoperative prostate specific antigen level, clinical stage, biopsy Gleason score, percentage of tumor involvement per biopsy specimen, transurethral prostate resection history, surgical experience and nerve-sparing technique were significantly associated with positive surgical margin rate. In multivariate analyses, preoperative prostate specific antigen level (OR: 1.03, p=0.06), percentage of tumor involvement per biopsy specimen (OR: 7,14, p<0,001), surgical experience (OR: 2.35, p=0.011) and unilateral nerve-sparing technique (OR: 1.81, p=0.018) were independent predictive factors for surgical margin positivity. Conclusion Preoperative prostate specific antigen level, percentage of tumor involvement per biopsy specimen, surgical experience and nerve-sparing technique are the most important predictive factors of surgical margin positivity in patients undergoing radical prostatectomy for localized prostate cancer. http://jurolsurgery.org/article_8777/Can-We-Predict-The-Surgical-Margin-Positivity-In-Patients-Treated-With-Radical-Prostatectomy-A-Multicenter-Cohort-Of-Turkish-Association-Of-Uro-oncologyProstate cancerradical prostatectomysurgical marginPSApercentage of tumor involvementsurgical experiencenerve sparing technique
collection DOAJ
language English
format Article
sources DOAJ
author Deniz Bolat
Saadettin Eskiçorapcı
Erdem Karabulut
Sümer Baltacı
Asıf Yıldırım
Sinan Sözen
Ferhat Ateş
Çağrı Akın Şekerci
Fatih Kurtuluş
Ayhan Dirim
Talha Muezzioğlu
Cavit Can1
Murat Bozlu
Hakan Gemalmaz
Sinan Ekici1
Haluk Özen
Levent Turkeri
spellingShingle Deniz Bolat
Saadettin Eskiçorapcı
Erdem Karabulut
Sümer Baltacı
Asıf Yıldırım
Sinan Sözen
Ferhat Ateş
Çağrı Akın Şekerci
Fatih Kurtuluş
Ayhan Dirim
Talha Muezzioğlu
Cavit Can1
Murat Bozlu
Hakan Gemalmaz
Sinan Ekici1
Haluk Özen
Levent Turkeri
Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology
Journal of Urological Surgery
Prostate cancer
radical prostatectomy
surgical margin
PSA
percentage of tumor involvement
surgical experience
nerve sparing technique
author_facet Deniz Bolat
Saadettin Eskiçorapcı
Erdem Karabulut
Sümer Baltacı
Asıf Yıldırım
Sinan Sözen
Ferhat Ateş
Çağrı Akın Şekerci
Fatih Kurtuluş
Ayhan Dirim
Talha Muezzioğlu
Cavit Can1
Murat Bozlu
Hakan Gemalmaz
Sinan Ekici1
Haluk Özen
Levent Turkeri
author_sort Deniz Bolat
title Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology
title_short Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology
title_full Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology
title_fullStr Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology
title_full_unstemmed Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology
title_sort can we predict the surgical margin positivity in patients treated with radical prostatectomy? a multicenter cohort of turkish association of uro-oncology
publisher Galenos Yayinevi
series Journal of Urological Surgery
issn 2148-9580
publishDate 2015-03-01
description Objective To analyze the parameters that predict the surgical margin positivity after radical prostatectomy for localized prostate cancer. Materials and Methods In this multicenter study, the data of 1607 consecutive patients undergoing radical prostatectomy for localized prostate cancer in 12 different clinics in Turkey between 1993-2011 were assessed. Patients who had neoadjuvant treatment were excluded. We assessed the relationship between potential predictive factors and surgical margin status after radical prostatectomy such as age, cancer characteristics, history of transurethral prostate resection, surgical experience and nerve-sparing technique by using univariate and multivariate Cox regression analyses and t test. Results The overall surgical margin positivity rate was 22.6% (359 patients). In univariate analyses, preoperative prostate specific antigen level, clinical stage, biopsy Gleason score, percentage of tumor involvement per biopsy specimen, transurethral prostate resection history, surgical experience and nerve-sparing technique were significantly associated with positive surgical margin rate. In multivariate analyses, preoperative prostate specific antigen level (OR: 1.03, p=0.06), percentage of tumor involvement per biopsy specimen (OR: 7,14, p<0,001), surgical experience (OR: 2.35, p=0.011) and unilateral nerve-sparing technique (OR: 1.81, p=0.018) were independent predictive factors for surgical margin positivity. Conclusion Preoperative prostate specific antigen level, percentage of tumor involvement per biopsy specimen, surgical experience and nerve-sparing technique are the most important predictive factors of surgical margin positivity in patients undergoing radical prostatectomy for localized prostate cancer.
topic Prostate cancer
radical prostatectomy
surgical margin
PSA
percentage of tumor involvement
surgical experience
nerve sparing technique
url http://jurolsurgery.org/article_8777/Can-We-Predict-The-Surgical-Margin-Positivity-In-Patients-Treated-With-Radical-Prostatectomy-A-Multicenter-Cohort-Of-Turkish-Association-Of-Uro-oncology
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