Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology
Objective To analyze the parameters that predict the surgical margin positivity after radical prostatectomy for localized prostate cancer. Materials and Methods In this multicenter study, the data of 1607 consecutive patients undergoing radical prostatectomy for localized prostate cancer in 12...
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Galenos Yayinevi
2015-03-01
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doaj-a218452c70b54ea1ae7612486aadfd382020-11-25T01:47:12ZengGalenos YayineviJournal of Urological Surgery2148-95802015-03-012171210.4274/jus.220Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-OncologyDeniz Bolat0Saadettin Eskiçorapcı1Erdem Karabulut2Sümer Baltacı3Asıf Yıldırım4Sinan Sözen5Ferhat Ateş6Çağrı Akın Şekerci7Fatih Kurtuluş8Ayhan Dirim9Talha Muezzioğlu10 Cavit Can111Murat Bozlu12Hakan Gemalmaz13Sinan Ekici114Haluk Özen15Levent Turkeri16İzmir Bozyaka Training and Research Hospital, Clinic of Urology, İzmir, Turkeyİzmir Bozyaka Training and Research Hospital, Clinic of Urology, İzmir, TurkeyHacettepe University Faculty of Medicine, Department of Biostatistics, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Urology, Ankara, TurkeyMedeniyet University Göztepe Training and Research Hospital, Clinic of Urology, İstanbul, TurkeyGazi University Faculty of Medicine, Department of Urology, Ankara, TurkeyGATA Haydarpaşa Training Hospital, Clinic of Urology, İstanbul, TurkeyMarmara University Faculty of Medicine , Department of Urology, İstanbul, TurkeyKemerburgaz University Faculty of Medicine, Department of Urology, İstanbul, TurkeyBaskent University Faculty of Medicine, Department of Urology, Ankara, TurkeyCelal Bayar University Faculty of Medicine, Department of Urology, Manisa, TurkeyOsman Gazi University Faculty of Medicine, Department of Urology, Eskisehir, TurkeyMersin University Faculty of Medicine, Department of Urology, Mersin, TurkeyAdnan Menderes University Faculty of Medicine, Department of Urology, Aydin, TurkeyMaltepe University Faculty of Medicine, Department of Urology, İstanbul, TurkeyHacettepe University Faculty of Medicine, Department of Urology, Ankara, TurkeyMarmara University Faculty of Medicine, Department of Urology, İstanbul, TurkeyObjective To analyze the parameters that predict the surgical margin positivity after radical prostatectomy for localized prostate cancer. Materials and Methods In this multicenter study, the data of 1607 consecutive patients undergoing radical prostatectomy for localized prostate cancer in 12 different clinics in Turkey between 1993-2011 were assessed. Patients who had neoadjuvant treatment were excluded. We assessed the relationship between potential predictive factors and surgical margin status after radical prostatectomy such as age, cancer characteristics, history of transurethral prostate resection, surgical experience and nerve-sparing technique by using univariate and multivariate Cox regression analyses and t test. Results The overall surgical margin positivity rate was 22.6% (359 patients). In univariate analyses, preoperative prostate specific antigen level, clinical stage, biopsy Gleason score, percentage of tumor involvement per biopsy specimen, transurethral prostate resection history, surgical experience and nerve-sparing technique were significantly associated with positive surgical margin rate. In multivariate analyses, preoperative prostate specific antigen level (OR: 1.03, p=0.06), percentage of tumor involvement per biopsy specimen (OR: 7,14, p<0,001), surgical experience (OR: 2.35, p=0.011) and unilateral nerve-sparing technique (OR: 1.81, p=0.018) were independent predictive factors for surgical margin positivity. Conclusion Preoperative prostate specific antigen level, percentage of tumor involvement per biopsy specimen, surgical experience and nerve-sparing technique are the most important predictive factors of surgical margin positivity in patients undergoing radical prostatectomy for localized prostate cancer. http://jurolsurgery.org/article_8777/Can-We-Predict-The-Surgical-Margin-Positivity-In-Patients-Treated-With-Radical-Prostatectomy-A-Multicenter-Cohort-Of-Turkish-Association-Of-Uro-oncologyProstate cancerradical prostatectomysurgical marginPSApercentage of tumor involvementsurgical experiencenerve sparing technique |
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Deniz Bolat Saadettin Eskiçorapcı Erdem Karabulut Sümer Baltacı Asıf Yıldırım Sinan Sözen Ferhat Ateş Çağrı Akın Şekerci Fatih Kurtuluş Ayhan Dirim Talha Muezzioğlu Cavit Can1 Murat Bozlu Hakan Gemalmaz Sinan Ekici1 Haluk Özen Levent Turkeri |
spellingShingle |
Deniz Bolat Saadettin Eskiçorapcı Erdem Karabulut Sümer Baltacı Asıf Yıldırım Sinan Sözen Ferhat Ateş Çağrı Akın Şekerci Fatih Kurtuluş Ayhan Dirim Talha Muezzioğlu Cavit Can1 Murat Bozlu Hakan Gemalmaz Sinan Ekici1 Haluk Özen Levent Turkeri Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology Journal of Urological Surgery Prostate cancer radical prostatectomy surgical margin PSA percentage of tumor involvement surgical experience nerve sparing technique |
author_facet |
Deniz Bolat Saadettin Eskiçorapcı Erdem Karabulut Sümer Baltacı Asıf Yıldırım Sinan Sözen Ferhat Ateş Çağrı Akın Şekerci Fatih Kurtuluş Ayhan Dirim Talha Muezzioğlu Cavit Can1 Murat Bozlu Hakan Gemalmaz Sinan Ekici1 Haluk Özen Levent Turkeri |
author_sort |
Deniz Bolat |
title |
Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology |
title_short |
Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology |
title_full |
Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology |
title_fullStr |
Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology |
title_full_unstemmed |
Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology |
title_sort |
can we predict the surgical margin positivity in patients treated with radical prostatectomy? a multicenter cohort of turkish association of uro-oncology |
publisher |
Galenos Yayinevi |
series |
Journal of Urological Surgery |
issn |
2148-9580 |
publishDate |
2015-03-01 |
description |
Objective
To analyze the parameters that predict the surgical margin positivity after
radical prostatectomy for localized prostate cancer.
Materials and Methods
In this multicenter study, the data of 1607 consecutive patients undergoing
radical prostatectomy for localized prostate cancer in 12 different clinics in
Turkey between 1993-2011 were assessed. Patients who had neoadjuvant
treatment were excluded. We assessed the relationship between potential
predictive factors and surgical margin status after radical prostatectomy
such as age, cancer characteristics, history of transurethral prostate resection,
surgical experience and nerve-sparing technique by using univariate and
multivariate Cox regression analyses and t test.
Results
The overall surgical margin positivity rate was 22.6% (359 patients). In
univariate analyses, preoperative prostate specific antigen level, clinical
stage, biopsy Gleason score, percentage of tumor involvement per biopsy
specimen, transurethral prostate resection history, surgical experience and
nerve-sparing technique were significantly associated with positive surgical
margin rate. In multivariate analyses, preoperative prostate specific antigen
level (OR: 1.03, p=0.06), percentage of tumor involvement per biopsy
specimen (OR: 7,14, p<0,001), surgical experience (OR: 2.35, p=0.011) and
unilateral nerve-sparing technique (OR: 1.81, p=0.018) were independent
predictive factors for surgical margin positivity.
Conclusion
Preoperative prostate specific antigen level, percentage of tumor involvement
per biopsy specimen, surgical experience and nerve-sparing technique are
the most important predictive factors of surgical margin positivity in patients
undergoing radical prostatectomy for localized prostate cancer.
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topic |
Prostate cancer radical prostatectomy surgical margin PSA percentage of tumor involvement surgical experience nerve sparing technique |
url |
http://jurolsurgery.org/article_8777/Can-We-Predict-The-Surgical-Margin-Positivity-In-Patients-Treated-With-Radical-Prostatectomy-A-Multicenter-Cohort-Of-Turkish-Association-Of-Uro-oncology |
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