SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.

Myeloid blood cells are largely resistant to infection with human immunodeficiency virus type 1 (HIV-1). Recently, it was reported that Vpx from HIV-2/SIVsm facilitates infection of these cells by counteracting the host restriction factor SAMHD1. Here, we independently confirmed that Vpx interacts w...

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Bibliographic Details
Main Authors: André Berger, Andreas F R Sommer, Jenny Zwarg, Matthias Hamdorf, Karin Welzel, Nicole Esly, Sylvia Panitz, Andreas Reuter, Irene Ramos, Asavari Jatiani, Lubbertus C F Mulder, Ana Fernandez-Sesma, Frank Rutsch, Viviana Simon, Renate König, Egbert Flory
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22174685/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22174685/?tool=EBI

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