The Potential Role of Ferroptosis in Neonatal Brain Injury

Ferroptosis is an iron-dependent form of cell death that is characterized by early lipid peroxidation and different from other forms of regulated cell death in terms of its genetic components, specific morphological features, and biochemical mechanisms. Different initiation pathways of ferroptosis h...

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Main Authors: Yanan Wu, Juan Song, Yafeng Wang, Xiaoyang Wang, Carsten Culmsee, Changlian Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00115/full
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spelling doaj-a25c395f952847a4b7514384f3b31c122020-11-25T00:58:13ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-02-011310.3389/fnins.2019.00115434833The Potential Role of Ferroptosis in Neonatal Brain InjuryYanan Wu0Juan Song1Yafeng Wang2Xiaoyang Wang3Xiaoyang Wang4Carsten Culmsee5Carsten Culmsee6Carsten Culmsee7Changlian Zhu8Changlian Zhu9Henan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaInstitute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenHenan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaInstitute of Pharmacology and Clinical Pharmacy, University of Marburg, Marburg, GermanyCenter for Mind, Brain and Behavior, University of Marburg, Marburg, GermanyHenan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenFerroptosis is an iron-dependent form of cell death that is characterized by early lipid peroxidation and different from other forms of regulated cell death in terms of its genetic components, specific morphological features, and biochemical mechanisms. Different initiation pathways of ferroptosis have been reported, including inhibition of system Xc-, inactivation of glutathione-dependent peroxidase 4, and reduced glutathione levels, all of which ultimately promote the production of reactive oxygen species, particularly through enhanced lipid peroxidation. Although ferroptosis was first described in cancer cells, emerging evidence now links mechanisms of ferroptosis to many different diseases, including cerebral ischemia and brain hemorrhage. For example, neonatal brain injury is an important cause of developmental impairment and of permanent neurological deficits, and several types of cell death, including iron-dependent pathways, have been detected in the process of neonatal brain damage. Iron chelators and erythropoietin have both shown neuroprotective effects against neonatal brain injury. Here, we have summarized the potential relation between ferroptosis and neonatal brain injury, and according therapeutic intervention strategies.https://www.frontiersin.org/article/10.3389/fnins.2019.00115/fullhypoxic ischemic brain injuryintraventricular hemorrhagecell deathiron toxicitylipid peroxidationneonate
collection DOAJ
language English
format Article
sources DOAJ
author Yanan Wu
Juan Song
Yafeng Wang
Xiaoyang Wang
Xiaoyang Wang
Carsten Culmsee
Carsten Culmsee
Carsten Culmsee
Changlian Zhu
Changlian Zhu
spellingShingle Yanan Wu
Juan Song
Yafeng Wang
Xiaoyang Wang
Xiaoyang Wang
Carsten Culmsee
Carsten Culmsee
Carsten Culmsee
Changlian Zhu
Changlian Zhu
The Potential Role of Ferroptosis in Neonatal Brain Injury
Frontiers in Neuroscience
hypoxic ischemic brain injury
intraventricular hemorrhage
cell death
iron toxicity
lipid peroxidation
neonate
author_facet Yanan Wu
Juan Song
Yafeng Wang
Xiaoyang Wang
Xiaoyang Wang
Carsten Culmsee
Carsten Culmsee
Carsten Culmsee
Changlian Zhu
Changlian Zhu
author_sort Yanan Wu
title The Potential Role of Ferroptosis in Neonatal Brain Injury
title_short The Potential Role of Ferroptosis in Neonatal Brain Injury
title_full The Potential Role of Ferroptosis in Neonatal Brain Injury
title_fullStr The Potential Role of Ferroptosis in Neonatal Brain Injury
title_full_unstemmed The Potential Role of Ferroptosis in Neonatal Brain Injury
title_sort potential role of ferroptosis in neonatal brain injury
publisher Frontiers Media S.A.
series Frontiers in Neuroscience
issn 1662-453X
publishDate 2019-02-01
description Ferroptosis is an iron-dependent form of cell death that is characterized by early lipid peroxidation and different from other forms of regulated cell death in terms of its genetic components, specific morphological features, and biochemical mechanisms. Different initiation pathways of ferroptosis have been reported, including inhibition of system Xc-, inactivation of glutathione-dependent peroxidase 4, and reduced glutathione levels, all of which ultimately promote the production of reactive oxygen species, particularly through enhanced lipid peroxidation. Although ferroptosis was first described in cancer cells, emerging evidence now links mechanisms of ferroptosis to many different diseases, including cerebral ischemia and brain hemorrhage. For example, neonatal brain injury is an important cause of developmental impairment and of permanent neurological deficits, and several types of cell death, including iron-dependent pathways, have been detected in the process of neonatal brain damage. Iron chelators and erythropoietin have both shown neuroprotective effects against neonatal brain injury. Here, we have summarized the potential relation between ferroptosis and neonatal brain injury, and according therapeutic intervention strategies.
topic hypoxic ischemic brain injury
intraventricular hemorrhage
cell death
iron toxicity
lipid peroxidation
neonate
url https://www.frontiersin.org/article/10.3389/fnins.2019.00115/full
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