Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice

Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice

As 5-lipoxygenase (5-LO) is an emerging target in obesity and insulin resistance, we have investigated whether this arachidonate pathway is also implicated in the progression of obesity-related fatty liver disease. Our results show that 5-LO activity and 5-LO-derived product levels are significantly...

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Bibliographic Details
Main Authors: Marta López-Parra, Esther Titos, Raquel Horrillo, Natàlia Ferré, Ana González-Périz, Marcos Martínez-Clemente, Anna Planagumà, Jaime Masferrer, Vicente Arroyo, Joan Clària
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Journal of Lipid Research
Subjects:
arachidonate 5-LO
VLDL-TG
hepatic steatosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520345831

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http://www.sciencedirect.com/science/article/pii/S0022227520345831

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