Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis
Abstract Background Sepsis is a major cause of morbidity and mortality among neonates and infants. Antibiotics are a central part of the first line treatment for sepsis in neonatal intensive care units worldwide. However, the evidence on the clinical effects of the commonly used antibiotic regimens...
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doaj-a2c90d4d82624557a246f667bbcc2c662020-12-06T12:09:51ZengBMCSystematic Reviews2046-40532019-12-018111310.1186/s13643-019-1207-1Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysisSteven Kwasi Korang0Sanam Safi1Christian Gluud2Ulrik Lausten-Thomsen3Janus C. Jakobsen4Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Copenhagen University HospitalCopenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Copenhagen University HospitalCopenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Copenhagen University HospitalDepartment of Neonatology, Copenhagen University HospitalCopenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Copenhagen University HospitalAbstract Background Sepsis is a major cause of morbidity and mortality among neonates and infants. Antibiotics are a central part of the first line treatment for sepsis in neonatal intensive care units worldwide. However, the evidence on the clinical effects of the commonly used antibiotic regimens for sepsis in neonates remains scarce. This systematic review aims to assess the efficacy and harms of antibiotic regimens for neonatal sepsis. Methods Electronic searches will be conducted in MEDLINE, Embase, The Cochrane Library, CINAHL, ZETOC and clinical trial registries (clinicaltrials.gov and ISRCTN). We will include randomised controlled trials of different antibiotic regimens for sepsis of neonates and infants. Eligible interventions will be any antibiotic regimen. Two reviewers will independently screen, select, and extract data. The methodological quality of individual studies will be appraised following Cochrane methodology. Primary outcomes will be ‘all-cause mortality’ and ‘serious adverse events’. Secondary outcomes will be ‘need for respiratory support’, ‘need for circulatory support’, ‘neurodevelopmental impairment’, ototoxicity, nephrotoxicity and necrotizing enterocolitis. We plan to perform a meta-analysis with trial sequential analysis. Discussion This is the study protocol for a systematic review on the effects of different antibiotic regimens for neonatal sepsis. The results of this systematic review intent to adequately inform stakeholders or health care professionals in the field of neonatal sepsis, and to aid appropriate development of treatment guidelines. Systematic review registration PROSPERO reference number: CRD42019134300.https://doi.org/10.1186/s13643-019-1207-1SepsisNeonatesInfantsSeptic shockAntibioticsSystematic review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Steven Kwasi Korang Sanam Safi Christian Gluud Ulrik Lausten-Thomsen Janus C. Jakobsen |
spellingShingle |
Steven Kwasi Korang Sanam Safi Christian Gluud Ulrik Lausten-Thomsen Janus C. Jakobsen Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis Systematic Reviews Sepsis Neonates Infants Septic shock Antibiotics Systematic review |
author_facet |
Steven Kwasi Korang Sanam Safi Christian Gluud Ulrik Lausten-Thomsen Janus C. Jakobsen |
author_sort |
Steven Kwasi Korang |
title |
Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis |
title_short |
Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis |
title_full |
Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis |
title_fullStr |
Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis |
title_full_unstemmed |
Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis |
title_sort |
antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis |
publisher |
BMC |
series |
Systematic Reviews |
issn |
2046-4053 |
publishDate |
2019-12-01 |
description |
Abstract Background Sepsis is a major cause of morbidity and mortality among neonates and infants. Antibiotics are a central part of the first line treatment for sepsis in neonatal intensive care units worldwide. However, the evidence on the clinical effects of the commonly used antibiotic regimens for sepsis in neonates remains scarce. This systematic review aims to assess the efficacy and harms of antibiotic regimens for neonatal sepsis. Methods Electronic searches will be conducted in MEDLINE, Embase, The Cochrane Library, CINAHL, ZETOC and clinical trial registries (clinicaltrials.gov and ISRCTN). We will include randomised controlled trials of different antibiotic regimens for sepsis of neonates and infants. Eligible interventions will be any antibiotic regimen. Two reviewers will independently screen, select, and extract data. The methodological quality of individual studies will be appraised following Cochrane methodology. Primary outcomes will be ‘all-cause mortality’ and ‘serious adverse events’. Secondary outcomes will be ‘need for respiratory support’, ‘need for circulatory support’, ‘neurodevelopmental impairment’, ototoxicity, nephrotoxicity and necrotizing enterocolitis. We plan to perform a meta-analysis with trial sequential analysis. Discussion This is the study protocol for a systematic review on the effects of different antibiotic regimens for neonatal sepsis. The results of this systematic review intent to adequately inform stakeholders or health care professionals in the field of neonatal sepsis, and to aid appropriate development of treatment guidelines. Systematic review registration PROSPERO reference number: CRD42019134300. |
topic |
Sepsis Neonates Infants Septic shock Antibiotics Systematic review |
url |
https://doi.org/10.1186/s13643-019-1207-1 |
work_keys_str_mv |
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1724399218073796608 |