Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation

Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation

Signalling through the endothelin receptor ETB, a class A GPCR, induces nitric oxide-mediated vasorelaxation. Here the authors present the crystal structures of the human ETB receptor bound to the peptide hormone endothelin-3 and in complex with the ETB-selective partial agonist IRL1620 and discuss...

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Bibliographic Details
Main Authors: Wataru Shihoya, Tamaki Izume, Asuka Inoue, Keitaro Yamashita, Francois Marie Ngako Kadji, Kunio Hirata, Junken Aoki, Tomohiro Nishizawa, Osamu Nureki
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07094-0

Internet

https://doi.org/10.1038/s41467-018-07094-0

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