N,N-disubstituted azines attenuate LPS-mediated neuroinflammation in microglia and neuronal apoptosis via inhibiting MAPK signaling pathways

N,N-disubstituted azines attenuate LPS-mediated neuroinflammation in microglia and neuronal apoptosis via inhibiting MAPK signaling pathways

Abstract Background Activated microglia interact with astrocytes and neuronal cells to induce neuroinflammation, which can contribute to the pathogenesis and progression of Alzheimer’s and Parkinson’s disease. To identify the most effective anti-neuroinflammatory agent, we designed and synthesized a...

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Bibliographic Details
Main Authors: Lalita Subedi, Oh Wook Kwon, Chaeho Pak, Goeun Lee, Kangwoo Lee, Hakwon Kim, Sun Yeou Kim
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Neuroscience
Subjects:
Azine
Lipopolysaccharide
Neuroinflammation
MAPK
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12868-017-0399-3

Internet

http://link.springer.com/article/10.1186/s12868-017-0399-3

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