Combined Antiviral Therapy Using Designed Molecular Scaffolds Targeting Two Distinct Viral Functions, HIV-1 Genome Integration and Capsid Assembly

Combined Antiviral Therapy Using Designed Molecular Scaffolds Targeting Two Distinct Viral Functions, HIV-1 Genome Integration and Capsid Assembly

Designed molecular scaffolds have been proposed as alternative therapeutic agents against HIV-1. The ankyrin repeat protein (AnkGAG1D4) and the zinc finger protein (2LTRZFP) have recently been characterized as intracellular antivirals, but these molecules, used individually, do not completely block...

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Bibliographic Details
Main Authors: Wannisa Khamaikawin, Somphot Saoin, Sawitree Nangola, Koollawat Chupradit, Supachai Sakkhachornphop, Sudarat Hadpech, Nattawat Onlamoon, Aftab A Ansari, Siddappa N Byrareddy, Pierre Boulanger, Saw-See Hong, Bruce E Torbett, Chatchai Tayapiwatana
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
anti-HIV-1 molecular scaffolds
designed ankyrin repeat proteins
designed zinc-finger proteins
HIV-1-resistant cells
SIV
SHIV
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300336

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http://www.sciencedirect.com/science/article/pii/S2162253116300336

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