Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus

• Main Authors: Bo Yang, Xiaohui Zhang, Dajun Zhang, Jing Hou, GuoWei Xu, Chaochao Sheng, Sk Mohiuddin Choudhury, Zixiang Zhu, Dan Li, Keshan Zhang, Haixue Zheng, Xiangtao Liu
• Format: Article
• Language: English
• Published: MDPI AG 2020-09-01
• Series: Pathogens
• Subjects: foot-and-mouth disease virus; immune escape; innate immune response; interferon; protein interaction; viral protein
• Online Access: https://www.mdpi.com/2076-0817/9/9/729
• ISSN: 2076-0817

Foot-and-mouth disease virus (FMDV) causes a highly contagious vesicular disease in cloven-hoofed livestock that results in severe consequences for international trade, posing a great economic threat to agriculture. The FMDV infection antagonizes the host immune responses via different signaling pathways to achieve immune escape. Strategies to escape the cell immune system are key to effective infection and pathogenesis. This review is focused on summarizing the recent advances to understand how the proteins encoded by FMDV antagonize the host innate and adaptive immune responses.