Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

Objective: Fibroblast growth factor 21 (FGF21) was recently discovered as stress-induced myokine during mitochondrial disease and proposed as key metabolic mediator of the integrated stress response (ISR) presumably causing systemic metabolic improvements. Curiously, the precise cell-non-autonomous...

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Main Authors: Mario Ost, Verena Coleman, Anja Voigt, Evert M. van Schothorst, Susanne Keipert, Inge van der Stelt, Sebastian Ringel, Antonia Graja, Thomas Ambrosi, Anna P. Kipp, Martin Jastroch, Tim J. Schulz, Jaap Keijer, Susanne Klaus
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815002148

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http://www.sciencedirect.com/science/article/pii/S2212877815002148

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