Factors influencing occurrence of peritonitis in Saudi children on peritoneal dialysis

Abstract Background The peritonitis rate among children treated with peritoneal dialysis (PD) has not been widely reported in Saudi Arabia. The study aim was to estimate the peritonitis rate per patient-year and investigate the factors associated with higher peritonitis rates in a sample of PD child...

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Main Authors: Khamisa Al Mokali, Zahra Al Sannaa, Faten Al Mutairi, Anwar E. Ahmed
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Pediatrics
Subjects:
Online Access:https://doi.org/10.1186/s12887-020-1936-2
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spelling doaj-a46e4e4232384817a3e270674c568d622021-01-31T16:04:32ZengBMCBMC Pediatrics1471-24312020-01-012011710.1186/s12887-020-1936-2Factors influencing occurrence of peritonitis in Saudi children on peritoneal dialysisKhamisa Al Mokali0Zahra Al Sannaa1Faten Al Mutairi2Anwar E. Ahmed3Division of Nephrology, Department of Paediatrics, King Abdullah Specialist Children’s Hospital, Ministry of the National Guard - Health Affairs CityQatif Central HospitalMaternity and Children HospitalKing Abdullah International Medical Research CenterAbstract Background The peritonitis rate among children treated with peritoneal dialysis (PD) has not been widely reported in Saudi Arabia. The study aim was to estimate the peritonitis rate per patient-year and investigate the factors associated with higher peritonitis rates in a sample of PD children at King Abdullah Specialist Children’s Hospital-Riyadh (KASCH-R), Saudi Arabia. Methods This retrospective cohort study included 27 PD children treated between September 2007 and December 2017 at KASCH-R. We recorded the children’s demographic and clinical data, and the frequency of peritonitis. Results The 27 PD children reviewed (63% girls; mean age = 7.32 years old; range, 1–14 years), resulted in 86 peritonitis diagnoses in which the overall recurrence rate (in at least one episode) was 58/86 (67.4%) with a 95% confidence interval (CI), 56.5 to 77.2%. The rate of peritonitis episodes per patient-year was 0.76 (1 episode per 1.31 patient-year). The generalized Poisson model identified older children (age >  10 years) (adjusted rate ratios [aRR] = 7.273, 95% CI: 1.562–33.860), congenital nephrosis (aRR = 4.677, 95% CI: 1.443–15.155), height below 3rd percentile (aRR = 4.689, 95% CI: 1.874–11.735), weight below 3rd percentile (aRR = 5.388, 95% CI: 1.678–17.302), low albumin level (aRR = 4.041, 95% CI: 2.053–7.956), two-week duration of antibiotic therapy (aRR = 2.947, 95% CI: 1.163–7.468), which were independently associated with a high peritonitis rate. Conclusions This study showed a high peritonitis rate in our center. Older children, congenital nephrosis, height and weight below the 3rd percentile, low albumin level, and long duration of antibiotic therapy were associated with a higher rate of peritonitis. An optimal peritonitis prevention strategy or best-practice guideline is needed to reduce and prevent peritonitis occurrence in our center.https://doi.org/10.1186/s12887-020-1936-2PeritonitisPeritoneal dialysisAcute kidney injury
collection DOAJ
language English
format Article
sources DOAJ
author Khamisa Al Mokali
Zahra Al Sannaa
Faten Al Mutairi
Anwar E. Ahmed
spellingShingle Khamisa Al Mokali
Zahra Al Sannaa
Faten Al Mutairi
Anwar E. Ahmed
Factors influencing occurrence of peritonitis in Saudi children on peritoneal dialysis
BMC Pediatrics
Peritonitis
Peritoneal dialysis
Acute kidney injury
author_facet Khamisa Al Mokali
Zahra Al Sannaa
Faten Al Mutairi
Anwar E. Ahmed
author_sort Khamisa Al Mokali
title Factors influencing occurrence of peritonitis in Saudi children on peritoneal dialysis
title_short Factors influencing occurrence of peritonitis in Saudi children on peritoneal dialysis
title_full Factors influencing occurrence of peritonitis in Saudi children on peritoneal dialysis
title_fullStr Factors influencing occurrence of peritonitis in Saudi children on peritoneal dialysis
title_full_unstemmed Factors influencing occurrence of peritonitis in Saudi children on peritoneal dialysis
title_sort factors influencing occurrence of peritonitis in saudi children on peritoneal dialysis
publisher BMC
series BMC Pediatrics
issn 1471-2431
publishDate 2020-01-01
description Abstract Background The peritonitis rate among children treated with peritoneal dialysis (PD) has not been widely reported in Saudi Arabia. The study aim was to estimate the peritonitis rate per patient-year and investigate the factors associated with higher peritonitis rates in a sample of PD children at King Abdullah Specialist Children’s Hospital-Riyadh (KASCH-R), Saudi Arabia. Methods This retrospective cohort study included 27 PD children treated between September 2007 and December 2017 at KASCH-R. We recorded the children’s demographic and clinical data, and the frequency of peritonitis. Results The 27 PD children reviewed (63% girls; mean age = 7.32 years old; range, 1–14 years), resulted in 86 peritonitis diagnoses in which the overall recurrence rate (in at least one episode) was 58/86 (67.4%) with a 95% confidence interval (CI), 56.5 to 77.2%. The rate of peritonitis episodes per patient-year was 0.76 (1 episode per 1.31 patient-year). The generalized Poisson model identified older children (age >  10 years) (adjusted rate ratios [aRR] = 7.273, 95% CI: 1.562–33.860), congenital nephrosis (aRR = 4.677, 95% CI: 1.443–15.155), height below 3rd percentile (aRR = 4.689, 95% CI: 1.874–11.735), weight below 3rd percentile (aRR = 5.388, 95% CI: 1.678–17.302), low albumin level (aRR = 4.041, 95% CI: 2.053–7.956), two-week duration of antibiotic therapy (aRR = 2.947, 95% CI: 1.163–7.468), which were independently associated with a high peritonitis rate. Conclusions This study showed a high peritonitis rate in our center. Older children, congenital nephrosis, height and weight below the 3rd percentile, low albumin level, and long duration of antibiotic therapy were associated with a higher rate of peritonitis. An optimal peritonitis prevention strategy or best-practice guideline is needed to reduce and prevent peritonitis occurrence in our center.
topic Peritonitis
Peritoneal dialysis
Acute kidney injury
url https://doi.org/10.1186/s12887-020-1936-2
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