Genetic susceptibility, elevated blood pressure, and risk of atrial fibrillation: a Mendelian randomization study

Abstract Background Whether elevated blood pressure (BP) is a modifiable risk factor for atrial fibrillation (AF) is not established. We tested (1) whether the association between BP and risk of AF is causal, (2) whether it varies according to individual’s genetic susceptibility for AF, and (3) the...

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Bibliographic Details
Main Authors: Milad Nazarzadeh, Ana-Catarina Pinho-Gomes, Zeinab Bidel, Dexter Canoy, Abbas Dehghan, Karl Smith Byrne, Derrick A. Bennett, George Davey Smith, Kazem Rahimi
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Genome Medicine
Subjects:
Online Access:https://doi.org/10.1186/s13073-021-00849-3