Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics

Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics

Ancestral sequence reconstruction is a powerful method for inferring ancestors of modern enzymes and for studying structure–function relationships of enzymes. We have previously applied this approach to haloalkane dehalogenases (HLDs) from the subfamily HLD-II and obtained thermodynamically highly s...

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Bibliographic Details
Main Authors: Petra Babkova, Zuzana Dunajova, Radka Chaloupkova, Jiri Damborsky, David Bednar, Martin Marek
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Enzyme
Haloalkane dehalogenase
Ancestral sequence reconstruction
Thermostability
X-ray crystallography
Protein simulations
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702030310X

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http://www.sciencedirect.com/science/article/pii/S200103702030310X

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