PA from a Recent H9N2 (G1-Like) Avian Influenza a Virus (AIV) Strain Carrying Lysine 367 Confers Altered Replication Efficiency and Pathogenicity to Contemporaneous H5N1 in Mammalian Systems

PA from a Recent H9N2 (G1-Like) Avian Influenza a Virus (AIV) Strain Carrying Lysine 367 Confers Altered Replication Efficiency and Pathogenicity to Contemporaneous H5N1 in Mammalian Systems

Egypt is a hotspot for H5- and H9-subtype avian influenza A virus (AIV) infections and co-infections in poultry by both subtypes have been frequently reported. However, natural genetic reassortment of these subtypes has not been reported yet. Here, we evaluated the genetic compatibility and replicat...

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Bibliographic Details
Main Authors: Ahmed Mostafa, Sara H. Mahmoud, Mahmoud Shehata, Christin Müller, Ahmed Kandeil, Rabeh El-Shesheny, Hanaa Z. Nooh, Ghazi Kayali, Mohamed A. Ali, Stephan Pleschka
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Viruses
Subjects:
avian influenza
H5N1
H9N2
R367K
reassortment
pathogenicity
Online Access:https://www.mdpi.com/1999-4915/12/9/1046

Internet

https://www.mdpi.com/1999-4915/12/9/1046

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