Congenital Cataract in Gpr161vl/vl Mice Is Modified by Proximal Chromosome 15.

Congenital Cataract in Gpr161vl/vl Mice Is Modified by Proximal Chromosome 15.

The morphology and severity of human congenital cataract varies even among individuals with the same mutation, suggesting that genetic background modifies phenotypic penetrance. The spontaneous mouse mutant, vacuolated lens (vl), arose on the C3H/HeSnJ background. The mutation disrupts secondary len...

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Bibliographic Details
Main Authors: Bo I Li, Myka R Ababon, Paul G Matteson, Yong Lin, Vikas Nanda, James H Millonig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5279759?pdf=render

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