Effects of urate-lowering agents on arrhythmia vulnerability in post-infarcted rat hearts

Hyperuricemia has been shown to be associated with ventricular arrhythmias. However, the mechanisms remained unknown. We assessed whether different urate-lowering agents can attenuate arrhythmias through lowering urate itself or inhibiting xanthenes oxidize (XO) activity in infarcted rats. Male Wist...

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Bibliographic Details
Main Authors: Tsung-Ming Lee, Shinn-Zong Lin, Nen-Chung Chang
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316300032