Exploration of the sputum methylome and omics deconvolution by quadratic programming in molecular profiling of asthma and COPD: the road to sputum omics 2.0

Exploration of the sputum methylome and omics deconvolution by quadratic programming in molecular profiling of asthma and COPD: the road to sputum omics 2.0

Abstract Background To date, most studies involving high-throughput analyses of sputum in asthma and COPD have focused on identifying transcriptomic signatures of disease. No whole-genome methylation analysis of sputum cells has been performed yet. In this context, the highly variable cellular compo...

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Bibliographic Details
Main Authors: Espen E. Groth, Melanie Weber, Thomas Bahmer, Frauke Pedersen, Anne Kirsten, Daniela Börnigen, Klaus F. Rabe, Henrik Watz, Ole Ammerpohl, Torsten Goldmann
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Respiratory Research
Subjects:
Sputum
Omics
Transcriptome
Methylome
Deconvolution
RNA
Online Access:http://link.springer.com/article/10.1186/s12931-020-01544-4

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http://link.springer.com/article/10.1186/s12931-020-01544-4

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