Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models
Local anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group) were used in these experiments. A neurostimulation-guided sciati...
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Associação Brasileira de Divulgação Científica
2012-02-01
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200009 |
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doaj-a530118123274e31af9197dc340491c72020-11-25T01:08:50ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2012-02-01452147152Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain modelsA.M. SousaH.A. AshmawiL.S. CostaI.P. PossoA. SlullitelLocal anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group) were used in these experiments. A neurostimulation-guided sciatic nerve block was performed and 2% lidocaine or tramadol (1.25 and 5 mg) was perineurally injected in two different animal pain models. In the flinching behavior test, the number of flinches was evaluated and in the plantar incision model, mechanical and heat thresholds were measured. Motor effects of lidocaine and tramadol were quantified and a motor block score elaborated. Tramadol, 1.25 mg, completely blocked the first and reduced the second phase of the flinching behavior test. In the plantar incision model, tramadol (1.25 mg) increased both paw withdrawal latency in response to radiant heat (8.3 ± 1.1, 12.7 ± 1.8, 8.4 ± 0.8, and 11.1 ± 3.3 s) and mechanical threshold in response to von Frey filaments (459 ± 82.8, 447.5 ± 91.7, 320.1 ± 120, 126.43 ± 92.8 mN) at 5, 15, 30, and 60 min, respectively. Sham block or contralateral sciatic nerve block did not differ from perineural saline injection throughout the study in either model. The effect of tramadol was not antagonized by intraperitoneal naloxone. High dose tramadol (5 mg) blocked motor function as well as 2% lidocaine. In conclusion, tramadol blocks nociception and motor function in vivo similar to local anesthetics.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200009TramadolTramadol-N-oxideRatsPeripheral nervesLocal anesthesiaAnalgesia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A.M. Sousa H.A. Ashmawi L.S. Costa I.P. Posso A. Slullitel |
spellingShingle |
A.M. Sousa H.A. Ashmawi L.S. Costa I.P. Posso A. Slullitel Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models Brazilian Journal of Medical and Biological Research Tramadol Tramadol-N-oxide Rats Peripheral nerves Local anesthesia Analgesia |
author_facet |
A.M. Sousa H.A. Ashmawi L.S. Costa I.P. Posso A. Slullitel |
author_sort |
A.M. Sousa |
title |
Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models |
title_short |
Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models |
title_full |
Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models |
title_fullStr |
Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models |
title_full_unstemmed |
Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models |
title_sort |
percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
0100-879X 1414-431X |
publishDate |
2012-02-01 |
description |
Local anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group) were used in these experiments. A neurostimulation-guided sciatic nerve block was performed and 2% lidocaine or tramadol (1.25 and 5 mg) was perineurally injected in two different animal pain models. In the flinching behavior test, the number of flinches was evaluated and in the plantar incision model, mechanical and heat thresholds were measured. Motor effects of lidocaine and tramadol were quantified and a motor block score elaborated. Tramadol, 1.25 mg, completely blocked the first and reduced the second phase of the flinching behavior test. In the plantar incision model, tramadol (1.25 mg) increased both paw withdrawal latency in response to radiant heat (8.3 ± 1.1, 12.7 ± 1.8, 8.4 ± 0.8, and 11.1 ± 3.3 s) and mechanical threshold in response to von Frey filaments (459 ± 82.8, 447.5 ± 91.7, 320.1 ± 120, 126.43 ± 92.8 mN) at 5, 15, 30, and 60 min, respectively. Sham block or contralateral sciatic nerve block did not differ from perineural saline injection throughout the study in either model. The effect of tramadol was not antagonized by intraperitoneal naloxone. High dose tramadol (5 mg) blocked motor function as well as 2% lidocaine. In conclusion, tramadol blocks nociception and motor function in vivo similar to local anesthetics. |
topic |
Tramadol Tramadol-N-oxide Rats Peripheral nerves Local anesthesia Analgesia |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200009 |
work_keys_str_mv |
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