CK2 Inhibition Prior to Status Epilepticus Persistently Enhances KCa2 Function in CA1 Which Slows Down Disease Progression

CK2 Inhibition Prior to Status Epilepticus Persistently Enhances KCa2 Function in CA1 Which Slows Down Disease Progression

PurposeEpilepsy therapy is currently based on anti-seizure drugs that do not modify the course of the disease, i.e., they are not anti-epileptogenic in nature. Previously, we observed that in vivo casein kinase 2 (CK2) inhibition with 4,5,6,7-tetrabromotriazole (TBB) had anti-epileptogenic effects i...

Full description

Bibliographic Details
Main Authors: Felix Schulze, Steffen Müller, Xiati Guli, Lukas Schumann, Hannes Brehme, Till Riffert, Marco Rohde, Doreen Goerss, Simone Rackow, Anne Einsle, Timo Kirschstein, Rüdiger Köhling
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
temporal lobe epilepsy
patch-clamp
intracellular recording
field potential recording
video-EEG monitoring
Timm stain
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00033/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00033/full

Similar Items