CK2 Inhibition Prior to Status Epilepticus Persistently Enhances KCa2 Function in CA1 Which Slows Down Disease Progression
PurposeEpilepsy therapy is currently based on anti-seizure drugs that do not modify the course of the disease, i.e., they are not anti-epileptogenic in nature. Previously, we observed that in vivo casein kinase 2 (CK2) inhibition with 4,5,6,7-tetrabromotriazole (TBB) had anti-epileptogenic effects i...
Main Authors: | Felix Schulze, Steffen Müller, Xiati Guli, Lukas Schumann, Hannes Brehme, Till Riffert, Marco Rohde, Doreen Goerss, Simone Rackow, Anne Einsle, Timo Kirschstein, Rüdiger Köhling |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-02-01
|
Series: | Frontiers in Cellular Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.00033/full |
Similar Items
-
Status Epilepticus Enhances Depotentiation after Fully Established LTP in an NMDAR-Dependent but GluN2B-Independent Manner
by: Xiati Guli, et al.
Published: (2016-01-01) -
Acute epileptiform activity induced by gabazine involves proteasomal rather than lysosomal degradation of KCa2.2 channels
by: Steffen Müller, et al.
Published: (2018-04-01) -
ZD7288 Enhances Long-Term Depression at Early Postnatal Medial Perforant Path-Granule Cell Synapses
by: Xiati Guli, et al.
Published: (2012-01-01) -
Distinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity
by: Bernd Frerker, et al.
Published: (2020-02-01) -
Functional Metaplasticity of Hippocampal Schaffer Collateral-CA1 Synapses Is Reversed in Chronically Epileptic Rats
by: Mirko Rehberg, et al.
Published: (2017-01-01)